TY - JOUR AU - Corripio-Miyar, Yolanda AU - Mellanby, Richard J. AU - Morrison, Katy AU - McNeilly, Tom N. PY - 2017 DA - 2017/12/13 TI - 1,25-Dihydroxyvitamin D3 modulates the phenotype and function of Monocyte derived dendritic cells in cattle JO - BMC Veterinary Research SP - 390 VL - 13 IS - 1 AB - The active form of the vitamin D3, 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) has been shown to have major effects not only on physiological processes but also on the regulation of the immune system of vertebrates. Dendritic cells are specialised antigen presenting cells which are in charge of the initiation of T-cell dependant immune responses and as such are key regulators of responses towards pathogens. In this study we set out to evaluate the effects of 1,25-(OH)2D3 on the phenotype of cattle monocyte-derived dendritic cells (MoDCs) and how the conditioning with this vitamin affects the function of these myeloid cells. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-017-1309-8 DO - 10.1186/s12917-017-1309-8 ID - Corripio-Miyar2017 ER -