Molecular cloning and characterization of the family of feline leucine-rich glioma-inactivated (LGI) genes, and mutational analysis in familial spontaneous epileptic cats

Table 1 Physiochemical characteristics of the feline leucine-rich glioma-inactivated (LGI) proteins

Physiochemical characteristics	LGI1	LGI2	LGI3	LGI4
Amino acid	557	549	548	538
Total number of atoms	8959	8728	8683	8323
Molecular weight (Da)	63,817.99	62,249.12	61,887.77	58,979.10
Isoelectric point	8.39	6.21	8.46	7.60
Asp + Glu	56	63	51	49
Arg + Lys	61	58	56	50
Extinction coefficients	84520^a/83770^b	80955^a/80330^b	91050^a/90300^b	71805^a/70930^b
Aliphatic index	85.75	88.23	88.47	97.25
Instability index	42.89	53.34	44.27	47.50
Grand average of hydropathicity	−0.227	−0.119	−0.143	0.064

^aComputed value based on the assumption that all cysteine residues appear as half cysteine’s; ^bAssuming that no cysteine appears as a half cysteine

ISSN: 1746-6148