Fig. 2
From: Investigation of c-KIT and Ki67 expression in normal, preneoplastic and neoplastic canine prostate
Immunohistochemical analysis of canine prostatic tissue for c-KIT and Ki67. a Normal canine prostate. Normal epithelial cells showing specific membranous staining (black arrow). b Ki67 expression in canine prostatic tissue. Arrows indicate positive nuclear expression in basal and stromal cells and no expression in luminal cells. c c-KIT expression in PIA lesion. Epithelial atrophic cells showed membranous and cytoplasmic c-KIT staining (arrows). d Ki67 expression in PIA lesion. There is positive nuclear expression in basal epithelial atrophic cells. e Canine prostate cancer. Neoplastic cells show membranous and cytoplasmic staining. Few c-KIT-positive stromal cells are observed. f Ki67 expression in canine prostate cancer. Note a high number of neoplastic cells showing nuclear expression. DAB chromogen, Harris haematoxylin counterstain. 200×