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Table 3 Summary of pathogenicity (attenuation) studies of PEDV KD (P120), PEDV AA (P103) or PEDV 8aa (P40, P70 or P105) in 1–4 day old piglets

From: Trypsin-independent porcine epidemic diarrhea virus US strain with altered virus entry mechanism

Group Inoculum Age at inoculation (numbers) No. of death (fatality %) Clinical symptoms Virus shedding
1 PEDV KD P120 2-day old (N = 5) 3/5 (60%) Diarrhea: 3–9 DPI Started at 2 DPI
2 PEDV AA P103 2-day-old (N = 14) 7/14 (50%) Diarrhea: 2–9 DPI Started at 1 DPI
3 PEDV 8aa P40 2 or 4-day old (N = 24) 20/24 (83.3%) Diarrhea: 3–8 DPI Started at 2 DPI
4 PEDV 8aa P70 1-day-old (N = 15) 1/15 (6.7%)
1 died (non-PEDV related)
Loose stool at 1–2 DPI Limited virus shedding
5 PEDV 8aa P105 1- or 2-day old (N = 16) 0/16 (0%) No diarrhea Limited virus shedding
  1. After virus inoculation, piglets were observed daily for clinical signs and rectal swabs were collected daily for the determination of virus shedding for up to 14 days post inoculation. DPI, days post infection