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Table 2 Reference genes for canine OS and their cellular function(s)

From: Reference gene validation for gene expression normalization in canine osteosarcoma: a geNorm algorithm approach

Gene symbol Name Function
RPS5 Ribosomal protein S5 Ribosomal protein that is a component of the 40S subunit, belongs to the S7P family of ribosomal proteins
RPS19 Ribosomal protein S19 Ribosomal protein that is a component of the 40S subunit, belongs to the S19E family of ribosomal proteins
HPRT Hypoxanthine guanine phosphoribosyl transferase Purine metabolism, salvage of purines from degraded RNA
HNRNPH Heterogeneous nuclear ribonucleoprotein H RNA-binding protein that forms a complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport
RPL8 Ribosomal protein L8 Ribosomal protein that is a component of the 60S subunit which catalyzes protein synthesis
GAPDH Glyceraldehyde-3-phosphate dehydrogenase Enzyme in glycolysis and gluconeogenesis pathway
B2M β-2-Microglobulin Beta chain of MHC class I molecules
SRPR Signal recognition particle receptor Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system
GUSB β-glucuronidase Role in degradation of dermatan and keratin sulphates