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Fig. 2 | BMC Veterinary Research

Fig. 2

From: Immunogenic potential of a Salmonella Typhimurium live vaccine for pigs against monophasic Salmonella Typhimurium DT 193

Fig. 2

Kinetics of the antibody response after oral vaccination and challenge (OD%, mean ± standard deviation). Asterisks point to significant differences between the groups (p ≤ 0.05). B0 = study day 0, B1 = study day 21, B2 = study day 42, B3 = study day 48/49. a Following immunization (B2) significant differences between vaccinated and control animals became apparent. At the end of the challenge period both groups exhibit similar values (Swine Salmonella Ab Test). b The amount of IgM antibodies was nearly equivalent in both groups until challenge (B0 to B2). At B3 (day 6 post challenge), the IgM OD% values in the control group were found to be significantly increased to both, the IgM level of the control group at B2 and the IgM level at B3 of the vaccinated animals, which showed only a slight increase of STM-specific IgM due to the challenge infection (Ig-isotype specific in-house ELISA). c STM-specific IgA showed markedly increasing values in the vaccinated pigs during the vaccination period with a further increase during the challenge. In contrast, the control animals revealed only slightly increasing values during the whole animal trial (Ig-isotype specific in-house ELISA). d At the sampling point B0 and B1 statistical differences in terms of STM-specific IgG were neither detectable in the vaccinated nor in the control animals. Prior to and post challenge the vaccinated pigs showed significant higher values compared to the control group (Ig-isotype specific in-house ELISA)

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