Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid

BMC Veterinary Research

Table 3 Mean (± SEM) concentration of FA measured in transverse cryosections

Mean (± SEM) concentration of FA measured in transverse cryosections obtained from full thickness dorsum or groin skin from healthy Beagle dogs (n = 6) after topical application of a 10 mg/g FA suspension (Isathal®) for 24 h in four diffusion cell experiments. Skin samples were undamaged, shampooed or tape-stripped (n = 6 per group) prior to dosing. After exposure, the skin was swabbed prior to transverse cryosectioning. No significant differences were seen between the concentrations achieved in any site or treatment group (ANOVA, P > 0.05)

ISSN: 1746-6148