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Table 1 Mean (±SEM) individual and combined percentage recoveries of FA

From: Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid

Measurement (%) Site Treatment Group
Undamaged Shampooed Tape-stripped
Site of FA recovery Total drug Dorsum 87.2 ± 6.8 93.0 ± 6.7 92.9 ± 3.6
Groin 89.2 ± 5.4 89.2 ± 7.8 89.9 ± 6.0
Surface swab Dorsum 60.4 ± 15.8 80.5 ± 10.0 79.2 ± 6.0
Groin 77.2 ± 5.9 78.5 ± 12.0 80.4 ± 6.4
Skin cryosections Dorsum 26.9 ± 10.2 12.6 ± 4.0 13.7 ± 2.7
Groin 12.0 ± 3.3 10.7 ± 4.5 9.4 ± 3.6
Receptor fluid Dorsum 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Groin 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
  1. FA: fusidic acid. Mean (±SEM) individual and combined percentage recoveries of FA from in vitro diffusion cells containing dorsal or groin skin from healthy Beagle dogs (n = 6) after topical application of a 10 mg/g FA suspension (Isathal®) for 24 h. Skin samples were undamaged, shampooed or tape-stripped (n = 6 per group) prior to dosing. After exposure, the skin was swabbed prior to transverse cryosectioning and swabs, skin samples and receptor fluid analysed for FA content