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Table 1 Mean (±SEM) individual and combined percentage recoveries of FA

From: Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid

Measurement (%)

Site

Treatment Group

Undamaged

Shampooed

Tape-stripped

Site of FA recovery

Total drug

Dorsum

87.2 ± 6.8

93.0 ± 6.7

92.9 ± 3.6

Groin

89.2 ± 5.4

89.2 ± 7.8

89.9 ± 6.0

Surface swab

Dorsum

60.4 ± 15.8

80.5 ± 10.0

79.2 ± 6.0

Groin

77.2 ± 5.9

78.5 ± 12.0

80.4 ± 6.4

Skin cryosections

Dorsum

26.9 ± 10.2

12.6 ± 4.0

13.7 ± 2.7

Groin

12.0 ± 3.3

10.7 ± 4.5

9.4 ± 3.6

Receptor fluid

Dorsum

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

Groin

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

  1. FA: fusidic acid. Mean (±SEM) individual and combined percentage recoveries of FA from in vitro diffusion cells containing dorsal or groin skin from healthy Beagle dogs (n = 6) after topical application of a 10 mg/g FA suspension (Isathal®) for 24 h. Skin samples were undamaged, shampooed or tape-stripped (n = 6 per group) prior to dosing. After exposure, the skin was swabbed prior to transverse cryosectioning and swabs, skin samples and receptor fluid analysed for FA content