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Table 4 Summary of hematology data; mean (SD), N = 8

From: Safety evaluation of the interchangeable use of robenacoxib (Onsior™) tablets and solution for injection in dogs

Variable

(reference range and units) a

Day

Group 1

Group 2

Group 3

Group 4

P value

Treatment

Time

Red blood cell count

(5.8–7.8 106/μL)

−17

6.23

(1.14)

5.85

(0.38)

5.75

(0.37)

5.84

(0.28)

0.3548

<0.0001

−11

5.66

(0.34)

5.77

(0.19)

5.75

(0.27)

5.87

(0.23)

  

21

5.85

(0.49)

5.63

(0.46)

5.71

(0.48)

5.84

(0.46)

  

55

6.21

(0.59)

5.99

(0.36)

6.05

(0.42)

6.36

(0.38)

  

89

6.38

(0.51)

6.22

(0.47)

6.27

(0.26)

6.37

(0.48)

  

Hemoglobin

(14.1–18.7 g/dL)

−17

13.16

(2.23)

12.44

(0.72)

12.43

(0.77)

12.71

(0.56)

0.2896

<0.0001

−11

12.05

(0.32)

12.31

(0.49)

12.55

(0.48)

12.79

(0.43)

  

21

12.49

(0.82)

12.18

(0.92)

12.50

(0.93)

12.88

(0.87)

  

55

13.68

(1.11)

13.33

(0.96)

13.70

(0.82)

14.51

(0.56)

  

89

13.88

(0.76)

13.50

(1.06)

14.13

(0.37)

14.16

(0.71)

  

Hematocrit

(41.0–55.3%)

−17

42.60

(7.67)

39.50

(2.38)

39.66

(2.68)

40.48

(1.89)

0.1645

<0.0001

−11

38.48

(1.35)

38.93

(1.41)

39.68

(1.67)

40.64

(1.17)

  

21

39.18

(2.57)

37.68

(2.71)

38.98

(2.97)

40.18

(2.71)

  

55

42.58

(3.30)

41.06

(2.56)

42.58

(2.45)

44.84

(1.78)

  

89

43.29

(2.56)

41.90

(3.21)

43.86

(0.98)

44.24

(2.44)

  

Platelet count

(161.6–379.0 103/μL)

−17

297.13

(75.13)

268.00

(106.63)

384.75

(61.17)

318.63

(64.39)

0.9909

<0.0001

−11

320.75

(63.09)

287.75

(54.84)

366.38

(50.36)

296.75

(71.34)

  

21

323.50

(57.94)

317.88

(63.30)

352.75

(42.68)

309.00

(93.97)

  

55

300.13

(43.28)

275.00

(47.67)

326.75

(34.01)

287.75

(56.39)

  

89

275.88

(36.74)

257.50

(31.27)

308.00

(31.60)

267.38

(66.42)

  

White blood cell count (7.4–14.5 103/μL)

−17

9.64

(1.54)

8.27

(1.18)

9.93

(1.96)

9.34

(1.56)

0.0433

<0.0001

−11

9.45

(1.67)

8.58

(2.08)

10.05

(2.91)

9.12

(1.53)

  

21

8.39

(1.40)

6.93

(0.70)

8.54

(2.15)

6.95

(0.91)

  

55

9.14

(2.13)

7.11

(0.98)

8.63

(2.10)

7.26

(0.51)

  

89

9.47

(1.01)

7.95

(1.20)

9.83

(2.20)

9.12

(1.62)

  

Activated partial thromboplastin time

(sec) b

−17

11.35

(0.67)

11.56

(0.83)

11.63

(0.71)

11.44

(0.75)

0.8555

0.0859

−11

13.68

(1.36)

13.60

(1.71)

13.05

(1.20)

13.55

(0.95)

  

21

12.74

(0.78)

12.24

(1.01)

12.24

(0.35)

12.49

(1.22)

  

55

12.26

(1.05)

12.98

(2.25)

12.61

(2.20)

11.80

(1.30)

  

89

12.13

(0.91)

12.21

(1.85)

11.76

(0.57)

11.91

(0.67)

  
  1. a These reference ranges have been derived from healthy young mongrel dogs (n = 124) and have been provided by the animal supplier. They are to be used for information only and the two values collected before the dosing period (at Day −17 and −11) should be used for interpretation in the context of this study
  2. b Not available in mongrel dogs
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BMC Veterinary Research

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