Table 2 Summary of MIC range, MIC50 and MIC90 values (μg/ml) of the isolated Mycoplasma synoviae strains with the suggested non-official breakpoints (in μg/ml; S: susceptible, R: resistant) and MIC values for the type strain WVU1853
Non-official breakpoints | WVU1853 initial | WVU1853 final | Range initial | Range final | MIC50 initial | MIC50 final | MIC90 initial | MIC90 final | |
|---|---|---|---|---|---|---|---|---|---|
Fluoroquinolones | |||||||||
Enrofloxacin | S ≤ 0.5; R ≥ 2 [5] | 0.312 | 1.25 | 0.312 – >10 | 0.312 – >10 | 1.25 | 1.25 | >10 | >10 |
Difloxacin | S ≤ 0.5; R ≥ 4 [5] | 1.25–2.5 | 1.25–2.5 | 0.625 – >10 | 0.625 – >10 | 2.5 | 2.5 | 10 | >10 |
Aminocyclitol | |||||||||
Spectinomycin | S ≤ 2; R > 4 [28] | 2 | 8 | ≤0.25–8 | 1–16 | 2 | 2 | 4 | 8 |
Aminoglycoside | |||||||||
Neomycin | S ≤ 4; R > 4 [25] | 64 – >64 | >64 | 4 – >64 | 8 – >64 | 32 | >64 | >64 | >64 |
Lincosamide | |||||||||
Lincomycin | S ≤ 2; R ≥ 8 [43] | 0.5 | 0.5 | ≤0.25 – >64 | ≤0.25 – >64 | 0.5 | 1 | 1 | 4 |
Tetracyclines | |||||||||
Doxycycline | S ≤ 4; R ≥ 16 [25] | ≤0.039 | 0.156 | ≤0.039–0.312 | 0.078–1.25 | 0.078 | 0.156 | 0.312 | 0.625 |
Oxytetracycline | S ≤ 4; R ≥ 16 [5] | ≤0.25 | 0.5 | ≤0.25–1 | ≤0.25–8 | ≤0.25 | 1 | 1 | 4 |
Chlortetracycline | S ≤ 4; R ≥ 16 [25] | 0.5 | 1 | ≤0.25–8 | ≤0.25–16 | 0.5 | 2 | 2 | 8 |
Macrolides | |||||||||
Tylosin | S ≤ 1; R ≥ 4 [5] | ≤0.25 | ≤0.25 | ≤0.25–2 | ≤0.25–8 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 |
Tilmicosin | S ≤ 8; R ≥ 32 [5] | ≤0.25 | ≤0.25 | ≤0.25–64 | ≤0.25 – >64 | ≤0.25 | ≤0.25 | 1 | 2 |
Tylvalosin | S ≤ 0.5; R > 2 [28] | ≤0.25 | ≤0.25 | ≤0.25–0.5 | ≤0.25–1 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 |
Pleuromutilins | |||||||||
Tiamulin | S ≤ 8; R ≥ 16 [7] | 0.078 | 0.078 | ≤0.039–0.625 | 0.078–1.25 | 0.078 | 0.156 | 0.312 | 0.312 |
Valnemulin | S ≤ 0.125; R > 0.125 [25] | ≤0.039 | ≤0.039 | ≤0.039 | ≤0.039 | ≤0.039 | ≤0.039 | ≤0.039 | ≤0.039 |
Amphenicol | |||||||||
Florfenicol | S ≤ 2; R ≥ 8 [25] | 1–2 | 1–4 | 0.5–8 | 1–16 | 4 | 8 | 8 | 8 |
Combination | |||||||||
Lincomycin: Spectinomycin | S ≤ 2(0.666/1.334); R > 4(1.332/2.668) [25] | 1 (0.333/0.667) | 1–2 (0.333/0.667–0.666/1.334) | 0.5–2 (0.167/0.333–0.666/1.334) | 0.5–4 (0.167/0.333–1.332/2.668) | 1 (0.333/0.667) | 1 (0.333/0.667) | 2 (0.666/1.334) | 2 (0.666/1.334) |