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Table 2 Summary of MIC range, MIC50 and MIC90 values (μg/ml) of the isolated Mycoplasma synoviae strains with the suggested non-official breakpoints (in μg/ml; S: susceptible, R: resistant) and MIC values for the type strain WVU1853

From: Antibiotic susceptibility profiles of Mycoplasma synoviae strains originating from Central and Eastern Europe

  Non-official breakpoints WVU1853 initial WVU1853 final Range initial Range final MIC50 initial MIC50 final MIC90 initial MIC90 final
Fluoroquinolones
 Enrofloxacin S ≤ 0.5; R ≥ 2 [5] 0.312 1.25 0.312 – >10 0.312 – >10 1.25 1.25 >10 >10
 Difloxacin S ≤ 0.5; R ≥ 4 [5] 1.25–2.5 1.25–2.5 0.625 – >10 0.625 – >10 2.5 2.5 10 >10
Aminocyclitol
 Spectinomycin S ≤ 2; R > 4 [28] 2 8 ≤0.25–8 1–16 2 2 4 8
Aminoglycoside
 Neomycin S ≤ 4; R > 4 [25] 64 – >64 >64 4 – >64 8 – >64 32 >64 >64 >64
Lincosamide
 Lincomycin S ≤ 2; R ≥ 8 [43] 0.5 0.5 ≤0.25 – >64 ≤0.25 – >64 0.5 1 1 4
Tetracyclines
 Doxycycline S ≤ 4; R ≥ 16 [25] ≤0.039 0.156 ≤0.039–0.312 0.078–1.25 0.078 0.156 0.312 0.625
 Oxytetracycline S ≤ 4; R ≥ 16 [5] ≤0.25 0.5 ≤0.25–1 ≤0.25–8 ≤0.25 1 1 4
 Chlortetracycline S ≤ 4; R ≥ 16 [25] 0.5 1 ≤0.25–8 ≤0.25–16 0.5 2 2 8
Macrolides
 Tylosin S ≤ 1; R ≥ 4 [5] ≤0.25 ≤0.25 ≤0.25–2 ≤0.25–8 ≤0.25 ≤0.25 ≤0.25 ≤0.25
 Tilmicosin S ≤ 8; R ≥ 32 [5] ≤0.25 ≤0.25 ≤0.25–64 ≤0.25 – >64 ≤0.25 ≤0.25 1 2
 Tylvalosin S ≤ 0.5; R > 2 [28] ≤0.25 ≤0.25 ≤0.25–0.5 ≤0.25–1 ≤0.25 ≤0.25 ≤0.25 ≤0.25
Pleuromutilins
 Tiamulin S ≤ 8; R ≥ 16 [7] 0.078 0.078 ≤0.039–0.625 0.078–1.25 0.078 0.156 0.312 0.312
 Valnemulin S ≤ 0.125; R > 0.125 [25] ≤0.039 ≤0.039 ≤0.039 ≤0.039 ≤0.039 ≤0.039 ≤0.039 ≤0.039
Amphenicol
 Florfenicol S ≤ 2; R ≥ 8 [25] 1–2 1–4 0.5–8 1–16 4 8 8 8
Combination
 Lincomycin: Spectinomycin S ≤ 2(0.666/1.334); R > 4(1.332/2.668) [25] 1 (0.333/0.667) 1–2 (0.333/0.667–0.666/1.334) 0.5–2 (0.167/0.333–0.666/1.334) 0.5–4 (0.167/0.333–1.332/2.668) 1 (0.333/0.667) 1 (0.333/0.667) 2 (0.666/1.334) 2 (0.666/1.334)