Table 1 Observed frequencies of nt230(del4) MDR1 mutation in related (affected known breeds, pure and crossed ones), and non-related (un-affected known breeds and mongrels) breeds in Israel
nt230(del4) MDR1 mutation allele breed genealogy | Breed | Frequency of nt230(del4) MDR1 mutation allele status [%] | |||||
|---|---|---|---|---|---|---|---|
Name | Status | Sample size | Homozygote (−/−) | Heterozygote (+/−) | Normal (+/+) | Frequency of nt230(del4) MDR1 mutation allele | |
Related | Australian Shepherd | Pure | 145 | 9.0% | 44.8% | 46.2% | 31.4% |
Australian Shepherd | Crosses | 32 | 0.0% | 15.6% | 84.4% | 7.8% | |
Border Collie | Pure | 261 | 2.3% | 5.0% | 92.7% | 4.8% | |
Border Collie | Crosses | 183 | 0.0% | 6.0% | 94.0% | 3.0% | |
Border Collie X Australian Shepherd | Pure | 5 | 0.0% | 20.0% | 80.0% | 10.0% | |
Rough Collie | Pure | 20 | 5.0% | 45.0% | 50.0% | 27.5% | |
Rough Collie | Crosses | 49 | 2.0% | 4.1% | 93.9% | 4.1% | |
German Shepherd | Pure | 21 | 0.0% | 4.8% | 95.2% | 2.4% | |
German Shepherd | Crosses | 11 | 0.0% | 0.0% | 90.9% | 0.0% | |
White Swiss Shepherd | Pure | 12 | 8.3% | 16.7% | 75.0% | 16.7% | |
White Swiss Shepherd | Crosses | 4 | 0.0% | 0.0% | 75.0% | 0.0% | |
Shetland Sheepdog | Pure | 13 | 0.0% | 53.8% | 46.2% | 26.9% | |
Shetland Sheepdog | Crosses | 1 | 0.0% | 0.0% | 100.0% | 0.0% | |
Old English Sheepdog | Pure | 4 | 0.0% | 75.0% | 25.0% | 37.5% | |
Old English Sheepdog | Crosses | 0 | 0% | 0.0% | 0.0% | 0% | |
Non-Related | Others | Pure | 61 | 0.0% | 0.0% | 100.0% | 0.0% |
Others (mongrels) | Crosses | 594 | 0.0% | 1.9% | 98.1% | 0.9% | |