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Table 1 Observed frequencies of nt230(del4) MDR1 mutation in related (affected known breeds, pure and crossed ones), and non-related (un-affected known breeds and mongrels) breeds in Israel

From: Frequency of canine nt230(del4) MDR1 mutation in prone pure breeds, their crosses and mongrels in Israel - insights from a worldwide comparative perspective.

nt230(del4) MDR1 mutation allele breed genealogy Breed Frequency of nt230(del4) MDR1 mutation allele status [%]
Name Status Sample size Homozygote (−/−) Heterozygote (+/−) Normal (+/+) Frequency of nt230(del4) MDR1 mutation allele
Related Australian Shepherd Pure 145 9.0% 44.8% 46.2% 31.4%
Australian Shepherd Crosses 32 0.0% 15.6% 84.4% 7.8%
Border Collie Pure 261 2.3% 5.0% 92.7% 4.8%
Border Collie Crosses 183 0.0% 6.0% 94.0% 3.0%
Border Collie X Australian Shepherd Pure 5 0.0% 20.0% 80.0% 10.0%
Rough Collie Pure 20 5.0% 45.0% 50.0% 27.5%
Rough Collie Crosses 49 2.0% 4.1% 93.9% 4.1%
German Shepherd Pure 21 0.0% 4.8% 95.2% 2.4%
German Shepherd Crosses 11 0.0% 0.0% 90.9% 0.0%
White Swiss Shepherd Pure 12 8.3% 16.7% 75.0% 16.7%
White Swiss Shepherd Crosses 4 0.0% 0.0% 75.0% 0.0%
Shetland Sheepdog Pure 13 0.0% 53.8% 46.2% 26.9%
Shetland Sheepdog Crosses 1 0.0% 0.0% 100.0% 0.0%
Old English Sheepdog Pure 4 0.0% 75.0% 25.0% 37.5%
Old English Sheepdog Crosses 0 0% 0.0% 0.0% 0%
Non-Related Others Pure 61 0.0% 0.0% 100.0% 0.0%
Others (mongrels) Crosses 594 0.0% 1.9% 98.1% 0.9%
  1. ‘+’ stands for WT allele; ‘-’ stands for nt230(del4) MDR1 mutation allele