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Table 2 Sensitivities and specificities at the optimal cut-off concentrations (expressed as the fold elevation above the respective URL for the assay) and area under the ROC curve (AUROC) for serum gastrin concentrations to distinguish acid-suppressant (H2A and/or PPI)-treated or acid-suppressant-naïve dogs with CE from dogs diagnosed with gastrinoma (n = 14 historical positive controls)

From: Effect of gastric acid-suppressive therapy and biological variation of serum gastrin concentrations in dogs with chronic enteropathies

Group comparison AUROC Cut-off Sensitivity Specificity
all CE dogs vs. gastrinomaa 97% >1.8 × URL 100% 90%
>3.2 × URL 93% 95%
acid-suppressant-naïve CE dogs vs. gastrinomaa 98% >1.8 × URL 100% 92%
>3.2 × URL 93% 97%
acid-suppressant-treated CE dogs vs. gastrinomaa 95% >1.8 × URL 100% 82%
>10.3 × URL 57% 95%
H2A-treated CE dogs vs. gastrinomaa 97% >1.8 × URL 100% 90%
>3.2 × URL 93% 95%
PPI-treated CE dogs vs. gastrinomaa 91% >3.2 × URL 93% 77%
>10.3 × URL 57% 95%
  1. AUROC area under the ROC curve, CE chronic enteropathy, H2A histamine type-2 receptor antagonist, PPI proton pump inhibitor, URL upper reference limit
  2. ahistorical positive controls [4, 21,22,23,24,25,26,27,28,29,30]