Fig. 3

Paired serum gastrin concentrations were evaluated in initially acid-suppressant-naïve CE dogs that received either an H2A (n = 6) or a PPI alone or in combination with an H2A (n = 5) at their next recheck. Serum gastrin concentrations did numerically increase in those dogs receiving a PPI alone or in combination with an H2A (prior to antisecretory therapy: median = 11.4 ng/L, IQR = 9.9–19.6 ng/L, range = 9.9–33.1 ng/L; receiving gastric acid-suppressive therapy: median = 34.8 ng/L, IQR = 9.9–254.0 ng/L, range = 9.9–485.0 ng/L), but the difference did not reach significance (P = 0.1563). No difference in serum gastrin concentrations was seen in dogs given an H2A alone (prior to antisecretory therapy: median = 11.0 ng/L, IQR = 9.9–20.2 ng/L, range = 9.9–85.5 ng/L; receiving acid-suppressant therapy: median = 13.9 ng/L, IQR = 9.9–59.6 ng/L, range: 9.9–355.0 ng/L; P = 0.5938). Boxes: interquartile range (IQR), vertical lines within boxes: medians, whiskers: minimum to maximum data points; dashed line: upper limit of the RI (≤27.8 ng/L)