Fig. 2

Serum gastrin concentrations and gastric acid-suppressive (PPI and/or H2A)-treatment in dogs with CE. Serum gastrin concentrations were significantly higher in dogs with CE administered either a PPI alone (n = 15) or in combination (n = 2) with an H2A (group PPI (±H2A); median: 31.2 ng/L, IQR: 14.0–54.1 ng/L, range: 9.9–282.0 ng/L) compared to CE dogs treated with an H2A alone (group H2A; n = 34; median: 10.2 ng/L, IQR: 9.9–23.7 ng/L, range: 9.9–490.0 ng/L; P = 0.0053) and those not receiving any gastric acid-suppressive treatment (group No acid reducer; n = 180; median: 9.9 ng/L, IQR: 9.9–17.4 ng/L, range: 9.9–571.0 ng/L; P = 0.0001). No significant difference was seen between H2A-treated CE dogs and dogs receiving no antisecretory treatment (P = 0.7312). Boxes: interquartile range (IQR), vertical lines within boxes: medians, whiskers: minimum to maximum data points; dashed line: upper limit of the RI (≤27.8 ng/L)