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Fig. 1 | BMC Veterinary Research

Fig. 1

From: A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models

Fig. 1

Effects of PEA-Q on CAR-induced paw oedema and heat hyperalgesia. Paw oedema and hyperalgesia were measured at the time points indicated. Oral treatment with PEA-Q (10 and 20 mg/kg) produced a significant improvement in paw volume that, unlike meloxicam, lasted up to the latest time point (a). In addition, PEA-Q was more effective in decreasing the hyperalgesia compared meloxicam (b). See Methods for further details. Values are means ± SEM of 10 animals for each group. *p < 0.05, **p < 0.001 and ***p < 0.0001 vs previous time point. #p < 0.05, ##p < 0.001, ###p < 0.0001 vs CAR + vehicle. ° p < 0.05 and °°° p < 0.0001 vs CAR + meloxicam. The exact p values are reported in the text

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