Table 2 Calculated total daily dose of cefquinome required to achieve the specific activity (%TMIC > 50% or 80%) against E. coli isolates from black swans with diverse MIC values
MIC (μg/mL) for E. coli isolates | Total daily dose (mg/kg) of cefquinome required to achieve | |||
|---|---|---|---|---|
%TMIC > 50% | %TMIC > 80% | |||
24-h interval | 12-h intervals | 24-h interval | 12-h intervals | |
0.031 | 0.45 | 0.14 | 3.88 | 0.38 |
0.063 | 0.89 | 0.24 | 7.95 | 0.72 |
0.125 | 1.86 | 0.48 | 16.4 | 1.68 |
0.25 | 3.25 | 0.98 | 33.7 | 2.96 |
0.5 | 7.38 | 1.94 | 67.3 | 6.54 |
1 | 14.6 | 3.86 | 132.7 | 12.9 |
2 | 29.7 | 7.72 | 264.2 | 27.4 |
8 | 115.1 | 31.2 | − | 106.6 |