Parameter | Unit | IV | IM |
---|
Ka | 1/h | — | 5.64 ± 3.07 |
A | μg/mL | 10.7 ± 4.97 | — |
α | 1/h | 2.27 ± 0.23 | — |
Kel | 1/h | — | 0.43 ± 0.03 |
B | μg/mL | 4.20 ± 1.91 | — |
β | 1/h | 0.42 ± 0.09 | — |
Vss
| L/kg | 0.32 ± 0.17 | — |
T1/2Ka
| h | — | 0.12 ± 0.04 |
T1/2α
| h | 0.31 ± 0.03 | — |
T1/2Ke
| h | — | 1.62 ± 0.11 |
T1/2β
| h | 1.69 ± 0.85 | — |
Tmax
| h | — | 0.39 ± 0.19 |
Cmax
| μg/mL | — | 5.71 ± 1.43 |
AUC | μg·h/mL | 16.5 ± 4.92 | 12.17 ± 4.32 |
ClB
| L/kg·h | 0.13 ± 0.04 | — |
F | % | — | 74.2 ± 26.3 |
- A, zero-time intercept of the distribution slope in the compartment model; B, zero-time inter of decline in plasma concentration of drug; α, distribution rate constant; β, elimination constant; Ke, constant of elimination rate; Ka, constant of absorption rate; T1/2Kel, elimination half-life; T1/2α, the distribution half-life; T1/2β, the half-life of elimination; T1/2Ka, absorption half-life; Vss, the apparent steady-state volume of distribution; ClB, total body clearance; AUC, total area under the concentration–time curve from zero to infinity; Tmax, time to Cmax from time zero; Cmax, peak plasma concentration; F, bioavailability