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Table 5 Predicted doses of marbofloxacin for three durations of activity (24, 48 and 72 h)a

From: Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling

  

Target Attainment Rate

  

P.multocida

A.pleuropneumoniae

Dose duration

Level of bacterial kill

50%

90%

50%

90%

0-24 h

Bacteriostatic

0.12

0.29

0.03

0.07

Bactericidal

0.27

0.64

0.05

0.12

4 log10 reduction

0.43

1.01

0.06

0.14

0-48 h

Bacteriostatic

0.19

0.44

0.16

0.39

Bactericidal

0.40

0.95

0.28

0.66

4 log10 reduction

0.64

1.51

0.34

0.82

0-72 h

Bacteriostatic

0.26

0.60

0.22

0.53

Bactericidal

0.56

1.31

0.38

0.92

4 log10 reduction

0.88

2.08

0.47

1.14

  1. aMonte Carlo Simulation to achieve 50 and 90% target attainment rates for two levels of bacterial kill and three action durations