BMC Veterinary Research

Table 4 Predicted once daily doses of marbofloxacin at steady state in pigs of three ages (weeks): 27 (A), 16 (B) and 12 (C)^a

From: Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling

	Predicted daily doses (mg/kg)	Target Attainment Rate
	Predicted daily doses (mg/kg)	50%	90%
A.
P. multocida	Bacteriostatic	0.08	0.19
	Bactericidal	0.18	0.43
	Virtual eradication	0.28	0.67
A. Pleuropneumoniae	Bacteriostatic	0.07	0.17
	Bactericidal	0.12	0.29
	4log₁₀ reduction	0.15	0.36
B.
P. multocida	Bacteriostatic	0.09	0.21
	Bactericidal	0.20	0.45
	Virtual eradication	0.32	0.72
A. pleuropneumoniae	Bacteriostatic	0.08	0.17
	Bactericidal	0.13	0.30
	4log₁₀ reduction	0.17	0.37
C.
P. multocida	Bacteriostatic	0.13	0.28
	Bactericidal	0.28	0.59
	Virtual eradication	0.45	0.94
A. pleuropneumoniae	Bacteriostatic	0.10	0.22
	Bactericidal	0.18	0.39
	4log₁₀ reduction	0.22	0.48

^aMonte Carlo simulation to achieve 50 and 90% target attainment rates at steady state for three levels of bacterial kill

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