Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling

Table 1 P. multocida PK/PD modelling of in vitro marbofloxacin time-kill curves (mean, standard deviation, n = 6)

Parameter (units)	Broth		Serum
Parameter (units)	Mean	SD (CV%)	Mean	SD (CV%)
Log E₀ (CFU/mL)	2.66	0.26	2.70	0.32
Log E_max (CFU/mL)	−7.28	0.37	−5.65	1.43
Log E_max - Log E₀ (CFU/mL)	−9.95	0.11	−8.35	1.11
Gamma	3.26	1.48	1.95	0.23
AUC_24h/MIC for bacteriostatic action (h)	26.5	4.65 (17.5)	20.9	2.31(11.1)
AUC_24h/MIC₅₀(h)	38.0	8.05 (21.2)	30.5	5.39 (17.7)
AUC_24h/MIC for bactericidal action (h)	41.8	7.79 (18.7)	45.2	5.58 (12.3)
AUC_24h/MIC for 4 log10 reduction (h)	48.9	10.8 (22.0)	71.7	34.0 (47.4)

E0 = difference in number of organisms (CFU/mL) in control sample in absence of drug between time 0 and 24 h; E_max = difference in number of organisms (CFU/mL) in presence of marbofloxacin between time 0 and 24 h; AUC₂₄/MIC₅₀ = concentration producing reduction in count to 50% of the E_max; Gamma = slope of the curve; detection limit = 33 CFU/mL

ISSN: 1746-6148