Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study

Table 1 Osmolarity, hematocrit and platelet counts prior to (T₀), and at 5 (T₅), 60 (T₆₀) and 120 (T₁₂₀) minutes after administration of mannitol and hypertonic saline (HTS)

Variable	Time point	Osmotherapeutic solution and sample size				P value
Variable	Time point	Sample size	Mannitol	Sample size	HTS	P value
Osmolarity (RI: 300-310 mOsm/L)	T₀	15	312 (308–327)	15	311 (309–320)	0.89
	T₅	15	329 (321–339)*	15	336 (324–340)*	0.96
	T₆₀	11	326 (318–341)*	12	324 (317–336)*	0.62
	T₁₂₀	8	327 (316-334)	11	326 (319–334)*	0.59
Hematocrit (RI: 0.39-0.57 L/L)	T₀	15	0.44 (0.35–0.49)	15	0.41 (0.37–0.49)	0.97
	T₅	15	0.37 (0.31–0.44)	15	0.37 (0.34–0.42)	0.68
	T₆₀	11	0.37 (0.35–0.41)	12	0.38 (0.37–0.42)	0.42
	T₁₂₀	8	0.42 (0.35–0.44)	11	0.40 (0.36–0.42)	0.70
Platelet count (RI: 150-400 × 10⁹/L)	T₀	15	221 (167–375)	15	237 (173–312)	0.91
	T₅	15	202 (157–314)	15	202 (179–287)	0.82
	T₆₀	11	207 (169–344)	12	177 (134–284)	0.56
	T₁₂₀	8	214 (188–393)	11	205 (141–269)	0.31

Values are shown as median (interquartile range), RI reference intervals; * values differing significantly from T₀ (P < 0.05)