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Table 1 Schedule of study activities

From: Efficacy and safety of oral robenacoxib (tablet) for the treatment of pain associated with soft tissue surgery in client-owned dogs

Study Days Activity
Day −14 to −2 Pre-enrollment visit
Blood and urine sample collection
Prior to enrollment Review clinical pathology results for animal eligibility
Day −1 to 0 Physical examination
Body weight determination
Begin acclimatization at least 2 h before performing the baseline CMPS-SF assessment
Day 0 Baseline pain assessment using CMPS-SF
First treatment
Administration of butorphanol
Induction of anesthesia, perform soft tissue surgery, extubation
Pain assessment using CMPS-SF
- 1.5, 3, 5 and 8 h (± 30 min) post-extubation
- between scheduled assessments, if pain intervention requireda
Day 1 Pain assessment using CMPS-SF 24 h (± 1 h) after initial treatment and prior to second treatment
Second treatment
Pain assessment using CMPS-SF
- 2 h and 8 h (± 30 min) post-treatment
- between scheduled assessments, if pain intervention requireda
Day 2 Pain assessment using CMPS-SF 48 h (± 1 h) after initial treatment and prior to third treatment
Third treatment
Pain assessment using CMPS-SF
- 2 h and 4 h (± 30 min) post treatment
- between scheduled assessments, if pain intervention requireda
- if pain intervention not required within 4 h (± 30 min) post treatment:
- Exit physical examination
- Body weight determination
- Blood and urine sample collection
Day 3 to 10 after study exit Post-study follow up phone call
  1. CMPS-SF Glasgow Composite Measure Pain Scale - Short Form, h hours, min minutes
  2. aif pain intervention required: administer intervention treatment, exit physical examination, determine body weight, collect blood and urine sample, remove dog from the study and monitor in clinic for 24 h