Efficacy and safety of oral robenacoxib (tablet) for the treatment of pain associated with soft tissue surgery in client-owned dogs

Table 1 Schedule of study activities

Study Days	Activity
Day −14 to −2	Pre-enrollment visit
Day −14 to −2	Blood and urine sample collection
Prior to enrollment	Review clinical pathology results for animal eligibility
Day −1 to 0	Physical examination
	Body weight determination
	Begin acclimatization at least 2 h before performing the baseline CMPS-SF assessment
Day 0	Baseline pain assessment using CMPS-SF
	First treatment
	Administration of butorphanol
	Induction of anesthesia, perform soft tissue surgery, extubation
	Pain assessment using CMPS-SF
	- 1.5, 3, 5 and 8 h (± 30 min) post-extubation
	- between scheduled assessments, if pain intervention required^a
Day 1	Pain assessment using CMPS-SF 24 h (± 1 h) after initial treatment and prior to second treatment
	Second treatment
	Pain assessment using CMPS-SF
	- 2 h and 8 h (± 30 min) post-treatment
	- between scheduled assessments, if pain intervention required^a
Day 2	Pain assessment using CMPS-SF 48 h (± 1 h) after initial treatment and prior to third treatment
	Third treatment
	Pain assessment using CMPS-SF
	- 2 h and 4 h (± 30 min) post treatment - between scheduled assessments, if pain intervention required^a
	- if pain intervention not required within 4 h (± 30 min) post treatment: - Exit physical examination - Body weight determination - Blood and urine sample collection
Day 3 to 10 after study exit	Post-study follow up phone call

CMPS-SF Glasgow Composite Measure Pain Scale - Short Form, h hours, min minutes
^aif pain intervention required: administer intervention treatment, exit physical examination, determine body weight, collect blood and urine sample, remove dog from the study and monitor in clinic for 24 h

ISSN: 1746-6148