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Fig. 2 | BMC Veterinary Research

Fig. 2

From: Integrated pharmacokinetic–Pharmacodynamic (PK/PD) model to evaluate the in vivo antimicrobial activity of Marbofloxacin against Pasteurella multocida in piglets

Fig. 2

Pharmacokinetic profiles of marbofloxacin in TCF. The tissue-cages were infected with P. multocida as described above, 24 h later administered with single intramuscularly doses of 0.15, 0.3,0.5,0.8,1.0,1.3,1.6,2.0 and 2.5 mg/kg marbofloxacin as BW. All TCF were sampled by puncture at 1, 3, 6, 9, 12, 24, 30, 36, 48, 72and 96 h after dosing. Marbofloxacin concentrations were determined using a HPLC method with fluorescence detection. But a small number of samples sampled on 96 h were undetected. Each symbol represents the mean ± standard deviation of the levels in the four tissue-cages. (Excel, Microsoft Office)

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BMC Veterinary Research

ISSN: 1746-6148

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