| Pain score (Fig. 1b) | Heart rate (Fig. 1c) | Respiratory rate (Fig. 1d) | Rectal temperature (Fig. 1e) | Carpus circumference (Fig. 1f) | Carpus skin temperature (Fig. 1g) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | Beats/min | Breaths/min | °C | Centimetres | °C | ||||||
Hours relative to LPS injection | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range |
−120 | 0.02 | 0–2 | 38.4 | 32–48 | 12.8 | 8–20 | 37.7 | 37.2–38.1 | 33.9 | 30.3–36.8 | 26.6 | 23.84–29.68 |
−96 | 0.02 | 0–1.5 | 38.0 | 32–40 | 14.8 | 12–20 | 37.5 | 37.2–38.0 | 33.7 | 30.6–36.5 | 28.5 | 24.62–32.70 |
−24 | 0.01 | 0–3 | 39.3 | 36–48 | 12.2 | 8–16 | 37.6 | 37.3–38.2 | 33.8 | 32.9–36.5 | 28.8 | 22.84–31.60 |
0 | 0.04 | 0–3 | 37.6 | 36–40 | 13.9 | 10–28 | 37.6 | 37.2–38.0 | 33.8 | 30.4–36.4 | 29.1 | 26.34–31.60 |
2 | 5.50** | 1–13 | 46.1 | 40–54 | 21.3 | 12–56 | 37.6 | 36.9–38.4 | 34.1 | 30.6–36.7 | 31.9* | 24.80–30.92 |
4 | 10.80*** | 7–14 | 47.9* | 40–52 | 32.8* | 14–68 | 37.9 | 37.0–38.5 | 34.4* | 30.6–37.5 | 32.1* | 25.36–33.66 |
8 | 6.82** | 3–11 | 46.5 | 40–56 | 17.9 | 12–28 | 38.5** | 38.1–39.1 | 34.4 | 30.4–37.5 | 32.2** | 29.68–34.28 |
16 | 3.60* | 1–7 | 43.0 | 32–52 | 16.0 | 12–28 | 38.3* | 38.0–38.7 | 34.9*** | 31.2–38.2 | 32.7*** | 26.50–35.30 |
24 | 0.88 | 0–8 | 38.4 | 28–44 | 12.2 | 9–20 | 37.6 | 37.2–37.9 | 34.9*** | 31.3–38.6 | 33.5*** | 32.30–34.68 |
36 | 0.03 | 0–1.5 | 36.6 | 32–40 | 10.5 | 8–12 | 37.6 | 37.1–37.9 | 35.0*** | 31.0–38.5 | 32.3** | 29.64–33.88 |
48 | 0 | 0–1 | 36.2 | 28–40 | 11.9 | 9–20 | 37.7 | 37.3–38.1 | 34.9*** | 31.0–38.5 | 32.6** | 30.42–34.02 |
72 | 0 | 0–1 | 35.2 | 32–40 | 11.2 | 8–16 | 37.5 | 36.9–38.0 | 34.9*** | 31.4–38.0 | 32.1** | 30.92–33.96 |
144 | 0 | 0–1 | 36.6 | 32–40 | 11.8 | 9–36 | 37.4 | 37.1–37.8 | 34.6*** | 30.8–38.0 | 30.2 | 28.64–32.08 |