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Table 6 Basic pharmacokinetic parameters describing the disposition of eprinomectin (B1a component) in plasma of sheep after administration of topical 0.5% w/v eprinomectin (EPRINEX® Pour-on, Merial), current Study 4 and data from other authors

From: Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep

Source Topical eprinomectin
(mg/kg body weight)
Cmax (ng/mL) Tmax (day) T1/2 (days) AUClast
(day*ng/mL)
Current Study 4 1.0 (n = 8a) 6.20 (± 1.71) 3.13 (± 2.99) 6.40 (± 2.95) 48.8 (± 19.2)
[19] 0.5 (n = 6b) 2.22 (± 0.88) 1.2 (± 0.4) 5.4 (± 0.7) 13.6 (± 4.8)
1.0 (n = 6c) 5.25 (± 2.7) 1.5 (± 0.5) 12.2 (± 5.8) 33.7 (± 22.5)
[16] 0.5 (n = 6d) NRe NR NR 56.0 (± 26.2)
[18] 0.5 (n = 6f) 2.28 (± 0.41) 3.17 (± 0.40) 2.20 (± 0.34) 16.2 (± 3.69)
0.5 (n = 6g) 2.30 (± 0.60) 3.00 (± 0.45) 1.85 (± 0.13) 15.5 (± 3.67)
  1. aFemale dry adult Merino Cross sheep, sampled up to 21 days post dose
  2. bFemale lactating adult Istrian Parmenka sheep, sampled up to 32 days post dose
  3. cFemale lactating adult Istrian Parmenka sheep, sampled up to 42 days post dose
  4. dFive month old sheep, sampled up to 21 days post dose
  5. eNot reported
  6. fFemale lactating (early-mid lactation) adult Pampina Cross sheep, sampled up to 35 days post dose
  7. gFemale lactating (mid-late lactation) adult Pampina Cross sheep, sampled up to 35 days post dose