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Table 4 Geometric mean fecal strongylid egg counts and percentage efficacy of topical 0.5% w/v eprinomectin (EPRINEX® Pour-on, Merial) administered once at 1 mg/kg body weight to naturally infected sheep under field conditions (Study 3)

From: Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep

Site(s) Occasion GMa (Range) strongylid eggs per gram counts Efficacy (%)b
Control (untreated) EPRINEX® Pour-on
Site 1, Germany 1 Pre-Treatmentc 437.7 (60–2150) 454.5 (70–1790) NCd
Post-Treatmente 276.2 (10–1490) 8.4 (0–120) 97.0
Site 2, Germany 2 Pre-Treatment 290.9 (90 – 3920) 416.0 (100–6480) NC
Post-Treatment 322.0 (90–3740) 5.7 (0–180) 98.2
Site 3, Italy 1 Pre-Treatment 1042.7 (108–4590) 1219.0 (126–12,456) NC
Post-Treatment 601.1 (162–6594) 12.1 (0–126) 98.0
Site 4, Italy 2 Pre-Treatment 633.0 (144–2064) 807.3 (480–4668) NC
Post-Treatment 519.9 (144–1200) 1.5 (0–36) 99.7
Sites 1 to 4 combined Pre-Treatment 531.8 (60–4590) 650.8f (70–6480) NC
Post-Treatment 406.4 (10–6594) 5.8g (0–180) 98.6
  1. aGM = geometric mean, computed by subtracting 1 from the anti-logarithm of the mean of ln(count + 1)
  2. bEfficacy (%) = 100×[(GM Control – GM EPRINEX® Pour-on)/GM Control]
  3. cPre-treatment fecal examination, Day −5
  4. dNC = Not calculated
  5. ePost-treatment fecal examination, Day 14
  6. fControl vs. EPRINEX® Pour-on, p = 0.2528
  7. gControl vs. EPRINEX® Pour-on, p < 0.0001