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Table 4 Geometric mean fecal strongylid egg counts and percentage efficacy of topical 0.5% w/v eprinomectin (EPRINEX® Pour-on, Merial) administered once at 1 mg/kg body weight to naturally infected sheep under field conditions (Study 3)

From: Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep

Site(s)

Occasion

GMa (Range) strongylid eggs per gram counts

Efficacy (%)b

Control (untreated)

EPRINEX® Pour-on

Site 1, Germany 1

Pre-Treatmentc

437.7 (60–2150)

454.5 (70–1790)

NCd

Post-Treatmente

276.2 (10–1490)

8.4 (0–120)

97.0

Site 2, Germany 2

Pre-Treatment

290.9 (90 – 3920)

416.0 (100–6480)

NC

Post-Treatment

322.0 (90–3740)

5.7 (0–180)

98.2

Site 3, Italy 1

Pre-Treatment

1042.7 (108–4590)

1219.0 (126–12,456)

NC

Post-Treatment

601.1 (162–6594)

12.1 (0–126)

98.0

Site 4, Italy 2

Pre-Treatment

633.0 (144–2064)

807.3 (480–4668)

NC

Post-Treatment

519.9 (144–1200)

1.5 (0–36)

99.7

Sites 1 to 4 combined

Pre-Treatment

531.8 (60–4590)

650.8f (70–6480)

NC

Post-Treatment

406.4 (10–6594)

5.8g (0–180)

98.6

  1. aGM = geometric mean, computed by subtracting 1 from the anti-logarithm of the mean of ln(count + 1)
  2. bEfficacy (%) = 100×[(GM Control – GM EPRINEX® Pour-on)/GM Control]
  3. cPre-treatment fecal examination, Day −5
  4. dNC = Not calculated
  5. ePost-treatment fecal examination, Day 14
  6. fControl vs. EPRINEX® Pour-on, p = 0.2528
  7. gControl vs. EPRINEX® Pour-on, p < 0.0001