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Table 2 Nematode counts and therapeutic efficacy against pulmonary and gastrointestinal nematodes of topical 0.5% w/v eprinomectin (EPRINEX® Pour-on, Merial) administered once at 1 mg/kg body weight to experimentally infected sheep (Study 1) or sheep with naturally acquired nematode infections (Study 2)

From: Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep

Study Nematode counts Probabilityc Efficacy (%)d
Control (untreated) EPRINEX® Pour-on
NI/NGa GMb (Range) NI/NG GM (Range)
Dictyocaulus filaria, adult
 1 10/10 30.1 (8–115) 0/10 0 <0.0001 100
Chabertia ovina, adult
 1 10/10 19.5 (5–70) 0/10 0 <0.0001 100
 2 9/10 5.7 (0–38) 0/10 0 <0.0001 100
Cooperia curticei, adult
 1 10/10 99.4 (10–260) 0/10 0 <0.0001 100
 2 9/10 674.9 (0–6820) 0/10 0 <0.0001 100
Haemonchus contortus, adult
 1 10/10 992.5 (450–1610) 0/10 0 <0.0001 100
 2 9/10 477.2 (0–11,030) 0/10 0 <0.0001 100
Nematodirus battus, adult
 1 10/10 148.8 (10–450) 0/10 0 <0.0001 100
 2 3/10 2.8 (0–130) 0/10 0 0.0465 100
Oesophagostomum venulosum, adult
 2 10/10 103.1 (3–893) 0/10 0 <0.0001 100
Strongyloides papillosus, adult e
 1 10/10 151.4 (30–700) 0/10 0 <0.0001 100
Teladorsagia circumcincta(pinnata/trifurcata), adult
 1 10/10 1700.6 (950–3770) 0/10 0.0 <0.0001 100
 2 10/10 6826.2 (1040–23,430) 3/10 1.7 (0–40) <0.0001 >99.9
Teladorsagia, inhibited fourth-stage larvae
 1 3/10 1.0 (0–10) 0/10 0 0.0465 100
 2 5/10 6.2 (0–240) 0/10 0 0.0214 100
Trichostrongylus axei, adult
 1 10/10 1169.3 (180–2430) 0/10 0 <0.0001 100
 2 8/10 99.7 (0–1280) 0/10 0 0.0003 100
Trichostrongylus colubriformis, adult
 1 10/10 1032.3 (560–1400) 0/10 0 <0.0001 100
 2 9/10 424.0 (0–13,947) 0/10 0 <0.0001 100
Trichostrongylus vitrinus, adult
 2 4/10 7.8 (0–146) 0/10 0 0.0155 100
  1. aNI/NG: Number of sheep Infected/Number of sheep in Group
  2. bGM = geometric mean, computed by subtracting 1 from the anti-logarithm of the mean of ln(count + 1)
  3. cProbability using the F-Test
  4. dEfficacy (%) = 100×[(GM Control – GM EPRINEX® Pour-on)/GM Control]
  5. eNaturally acquired infection