Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep

Table 2 Nematode counts and therapeutic efficacy against pulmonary and gastrointestinal nematodes of topical 0.5% w/v eprinomectin (EPRINEX® Pour-on, Merial) administered once at 1 mg/kg body weight to experimentally infected sheep (Study 1) or sheep with naturally acquired nematode infections (Study 2)

Study	Nematode counts				Probability^c	Efficacy (%)^d
	Control (untreated)		EPRINEX® Pour-on
	NI/NG^a	GM^b (Range)	NI/NG	GM (Range)
Dictyocaulus filaria, adult
1	10/10	30.1 (8–115)	0/10	0	<0.0001	100
Chabertia ovina, adult
1	10/10	19.5 (5–70)	0/10	0	<0.0001	100
2	9/10	5.7 (0–38)	0/10	0	<0.0001	100
Cooperia curticei, adult
1	10/10	99.4 (10–260)	0/10	0	<0.0001	100
2	9/10	674.9 (0–6820)	0/10	0	<0.0001	100
Haemonchus contortus, adult
1	10/10	992.5 (450–1610)	0/10	0	<0.0001	100
2	9/10	477.2 (0–11,030)	0/10	0	<0.0001	100
Nematodirus battus, adult
1	10/10	148.8 (10–450)	0/10	0	<0.0001	100
2	3/10	2.8 (0–130)	0/10	0	0.0465	100
Oesophagostomum venulosum, adult
2	10/10	103.1 (3–893)	0/10	0	<0.0001	100
Strongyloides papillosus, adult ^e
1	10/10	151.4 (30–700)	0/10	0	<0.0001	100
Teladorsagia circumcincta(pinnata/trifurcata), adult
1	10/10	1700.6 (950–3770)	0/10	0.0	<0.0001	100
2	10/10	6826.2 (1040–23,430)	3/10	1.7 (0–40)	<0.0001	>99.9
Teladorsagia, inhibited fourth-stage larvae
1	3/10	1.0 (0–10)	0/10	0	0.0465	100
2	5/10	6.2 (0–240)	0/10	0	0.0214	100
Trichostrongylus axei, adult
1	10/10	1169.3 (180–2430)	0/10	0	<0.0001	100
2	8/10	99.7 (0–1280)	0/10	0	0.0003	100
Trichostrongylus colubriformis, adult
1	10/10	1032.3 (560–1400)	0/10	0	<0.0001	100
2	9/10	424.0 (0–13,947)	0/10	0	<0.0001	100
Trichostrongylus vitrinus, adult
2	4/10	7.8 (0–146)	0/10	0	0.0155	100

^aNI/NG: Number of sheep Infected/Number of sheep in Group
^bGM = geometric mean, computed by subtracting 1 from the anti-logarithm of the mean of ln(count + 1)
^cProbability using the F-Test
^dEfficacy (%) = 100×[(GM Control – GM EPRINEX® Pour-on)/GM Control]
^eNaturally acquired infection

ISSN: 1746-6148