Fig. 2

Schematic representation of three H. parasuis autotransporters. Each panel shows the domains predicted using CD-search algorithm from NCBI in each protein. At the top, the protein found in non-virulent F9 strain (adhesin YadA) with leader sequence from VtaAs overrepresented in non-clinical isolates (in red) and translocator domain from group 1 VtaAs (in yellow) is shown. Below, representative proteins from group 1 (VtaA3, ACG50753; group 1 translocator domain indicated in yellow) and group 3 (VtaA13, ACG50752; group 3 translocator domain indicated in orange) from Nagasaki strain are shown. The depicted domains are: ESPR (Extended Signal Peptide of Type V secretion system, cd289765), LbR YadA-like (YadA-like, left-handed beta-roll cd12820), YadA stalk (Coiled stalk of trimeric autotransporter adhesion, cd 283,348), Collagen (Collagen triple helix repeat 20 copies, cd189968) and YadA anchor or translocator domain (YadA-like C-terminal region, cd281838). Accession numbers for proteins and domains are shown between brackets. Domains are represented with the same shapes between proteins. Mismatching colors within the same shapes denote low homology between domains from different proteins. Numbers below each protein representation correspond to amino acids