Fig. 6
Western immunoblot profile of brains from sheep challenged with caprine scrapie. Lanes 1–6: VV sheep (1: 1418; 2: 1419; 3: 1451; 4: 1452; 5: 1425, 6: 1424); lanes 7–12: LL141 sheep (7: 1319; 8: 1294; 9: 1293; 10: 1286; 11: 1329; 12: 1473); lanes 13–19: LF141 sheep (13: 1320; 14: 1287; 15: 1321; 16: 1302; 17: 1324; 18: 1323; 19: 1322); lanes 20–22: FF141 sheep (20: 1471; 21: 1472; 22: 1476). M: molecular mass markers; C: caprine classical scrapie II142; B: classical BSE; O: ovine classical scrapie (VV). For better visualisation, lanes 2, 3, 6 and controls were cropped from the original blots, indicated by the white boundary lines, to create a composite image. Reactivity with the N-terminal antibody P4 was reduced in LF141 and FF141 sheep, which is unlike classical scrapie