Fig. 2
Urinary concentrations of S100A8/A9 normalized against urine specific gravity (S100A8/A9USG) were significantly higher in newly diagnosed TCC/PCA dogs compared to dogs with non-neoplastic urinary tract (UT) diseases (P = 0.0088), dogs with neoplastic diseases not involving the urinary tract (P < 0.0001), and healthy control dogs (P < 0.0001); but did not differ from S100A8/A9USG measured in dogs with TCC/PCA undergoing cancer therapy (P = 0.2587) or dogs with a bacterial urinary tract infection (UTI; P = 0.1763). Boxes: interquartile range (IQR); vertical lines within boxes: medians; whiskers: determined by the outermost data points or values computed as (25th quartile – 1.5 × IQR) or (75th quartile +1.5 × IQR); dashed line: optimum cut-off concentration (≥109.9) to distinguish dogs with TCC/PCA from those of other groups; **significant difference at P < 0.01; ***significant difference at P < 0.001