TY - JOUR AU - Heilmann, Romy M. AU - McNiel, Elizabeth A. AU - Grützner, Niels AU - Lanerie, David J. AU - Suchodolski, Jan S. AU - Steiner, Jörg M. PY - 2017 DA - 2017/04/21 TI - Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma JO - BMC Veterinary Research SP - 112 VL - 13 IS - 1 AB - Onset of canine transitional cell carcinoma (TCC) and prostatic carcinoma (PCA) is usually insidious with dogs presenting at an advanced stage of the disease. A biomarker that can facilitate early detection of TCC/PCA and improve patient survival would be useful. S100A8/A9 (calgranulin A/B or calprotectin) and S100A12 (calgranulin C) are expressed by cells of the innate immune system and are associated with several inflammatory disorders. S100A8/A9 is also expressed by epithelial cells after malignant transformation and is involved in the regulation of cell proliferation and metastasis. S100A8/A9 is up-regulated in human PCA and TCC, whereas the results for S100A12 have been ambiguous. Also, the urine S100A8/A9-to-S100A12 ratio (uCalR) may have potential as a marker for canine TCC/PCA. Aim of the study was to evaluate the diagnostic accuracy of the urinary S100/calgranulins to detect TCC/PCA in dogs by using data and urine samples from 164 dogs with TCC/PCA, non-neoplastic urinary tract disease, other neoplasms, or urinary tract infections, and 75 healthy controls (nested case-control study). Urine S100A8/A9 and S100A12 (measured by species-specific radioimmunoassays and normalized against urine specific gravity [S100A8/A9USG; S100A12USG], urine creatinine concentration, and urine protein concentration and the uCalR were compared among the groups of dogs. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-017-1032-5 DO - 10.1186/s12917-017-1032-5 ID - Heilmann2017 ER -