Blood markers of fibrinolysis and endothelial activation in canine babesiosis

BMC Veterinary Research

Table 1 Concentrations of blood markers of fibrinolysis and endothelial activation in canine babesiosis

Parameter (unit)	Group	N	Mean ± SD / Median (interquartile range)	P value^* B0-B6	P value^** B0 - C	P value^*** B6 - C
TM (ng/ml)	B0	30	3.53 (2.65–4.25)	<0.001	0.001	0.009
	B6	30	1.47 (1.31–1.78)
	Control	10	1.98 (1.62–2.41)
ICAM-1 (ng/ml)	B0	30	6.75 (5.07–10.19)	0.007	0.866	0.636
	B6	28	6.42 (4.44–9.91)
	Control	10	7.59 (4.6–18.7)
HMGB-1 (ng/ml)	B0	30	47.88 (34.12–88.1)	<0.001	<0.001	0.524
	B6	28	17.59 (12.33–43.88)
	Control	10	15.71 (13.27–26.0)
PLG (%)	B0	30	85.5 (82.0–105.0)	0.011	0.053	0.906
	B6	27	103.0 (92.0–131.0)
	Control	10	104.0 (96.0–111.0)
PAI-1 (pg/ml)	B0	30	184.1 (92.67–405.96)	0.036	0.054	0.272
	B6	28	324.06 (176.59–608.05)
	Control	10	413.05 (371.78–540.97)
TAFI (ng/ml)	B0	30	461.15 ± 80.80	0.072	0.795	0.217
	B6	26	511.91 ± 140.65
	Control	10	453.92 ± 55.93
suPAR (pg/ml)	B0	30	4311.63 (3893.05–4840.3)	0.091	0.001	0.520
	B6	26	3725.3 (3277.2–4673.55)
	Control	10	3613.35 (3052.65–3893.05)
VCAM-1 (ng/ml)	B0	30	480.66 ± 59.21	0.841	0.026	0.056
	B6	29	478.44 ± 74.09
	Control	10	416.73 ± 113.4

Concentrations of soluble thrombomodulin (TM), soluble intercellular adhesive molecule-1 (ICAM-1), high mobility group box-1 protein (HMGB-1), plasminogen (PLG), plasminogen activator inhibitor-1 (PAI-1), thrombin activatable fibrinolysis inhibitor (TAFI), soluble urokinase receptor of plasminogen activator (suPAR) and soluble vascular adhesive molecule-1 (VCAM-1) in dogs with babesiosis at admission (B0), on the 6th day (B6) and healthy dogs (Control)
^* P value for differences between dependent samples on the day 0 and 6 (Wilcoxon matched pairs test and dependent t-test)
^** P value for differences between dogs with babesiosis day 0 compared to control (Mann-Whitney and t-test)
^*** P value for differences between dogs with babesiosis day 6 compared to control (Mann-Whitney and t-test)

ISSN: 1746-6148