| |
Control (n = 4)a
|
Infected (n = 6, c
n = 3)
|
|---|
|
BALF Cytokines:
|
|
IL-6 (pg/ml)
|
ND
|
434.2 (ND-2491.5)
|
|
IL-1β (pg/ml)
|
ND
|
1166.8 (ND-2808.1)
|
|
TNF-α (pg/ml)
|
129.5 (ND-410.4)
|
ND
|
|
BALF acute phase proteins:
|
|
CRP (ng/ml)
|
89.7 (39.5–189.6)
|
389.7 (192.6–554.4)
|
|
Hp (μg/ml)
|
6.7 (5.2–9.1)
|
6.2 (5.1–7.5)
|
|
BALF Cells:
|
|
Leukocytes (×109/l)
|
2.9 (1.8–5.1)
|
11.4 (7.8–16.9)**
|
|
Lymphocytes (×109/l)
|
0.1 (0–0.3)
|
c2.5 (0.8–6.1)
|
|
Alveolar Macrophage (×109/l)
|
1.7 (1.5–2.3)
|
c6.2 (4.5–10.6)
|
| |
Infected (pre-infection)b
|
Infected (8 hpi)
|
|
Serum acute phase proteins:
|
|
CRP (μg/ml)
|
49.7 (18.4–71.5)
|
202.2 (93.9–309)*
|
|
Hp (mg/ml)
|
0.7 (0.2–1.1)
|
0.7 (0.5–1.3)
|
|
Saliva acute phase proteins:
|
|
CRP (ng/ml)
|
3 (1.3–7.4)
|
27.9 (8.4–37.6)
|
|
Hp (μg/ml)
|
0.4 (0.2–1)
|
1.9 (1.3–3.6)*
|
- Results are expressed as median values (interquartile range). aDifferences between control and infected group in the BALF immediately after death. *p ≤ 0.05
- **p ≤ 0.01 Wilcoxon rank test. bDifferences within the infected group between the last time point of sampling (8 hpi) and prior to infection. *p ≤ 0.05 Wilcoxon signed ranks test. cLymphocytes and alveolar macrophages were not detectable in the BALF of three animals out of the infection group
- ND = not detectable because below detection limit
- Significant values are marked in bold
