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Table 2 Concentrations of cytokines (IL-6, IL-1 and TNF-α), acute phase proteins (CRP, Haptoglobin) and cells in different bodily fluids from control and infected animals

From: Host-pathogen interplay at primary infection sites in pigs challenged with Actinobacillus pleuropneumoniae

  Control (n = 4)a Infected (n = 6, c n = 3)
BALF Cytokines:
 IL-6 (pg/ml) ND 434.2 (ND-2491.5)
 IL-1β (pg/ml) ND 1166.8 (ND-2808.1)
 TNF-α (pg/ml) 129.5 (ND-410.4) ND
BALF acute phase proteins:
 CRP (ng/ml) 89.7 (39.5–189.6) 389.7 (192.6–554.4)
 Hp (μg/ml) 6.7 (5.2–9.1) 6.2 (5.1–7.5)
BALF Cells:
 Leukocytes (×109/l) 2.9 (1.8–5.1) 11.4 (7.8–16.9)**
 Lymphocytes (×109/l) 0.1 (0–0.3) c2.5 (0.8–6.1)
 Alveolar Macrophage (×109/l) 1.7 (1.5–2.3) c6.2 (4.5–10.6)
  Infected (pre-infection)b Infected (8 hpi)
Serum acute phase proteins:
 CRP (μg/ml) 49.7 (18.4–71.5) 202.2 (93.9–309)*
 Hp (mg/ml) 0.7 (0.2–1.1) 0.7 (0.5–1.3)
Saliva acute phase proteins:
 CRP (ng/ml) 3 (1.3–7.4) 27.9 (8.4–37.6)
 Hp (μg/ml) 0.4 (0.2–1) 1.9 (1.3–3.6)*
  1. Results are expressed as median values (interquartile range). aDifferences between control and infected group in the BALF immediately after death. *p ≤ 0.05
  2. **p ≤ 0.01 Wilcoxon rank test. bDifferences within the infected group between the last time point of sampling (8 hpi) and prior to infection. *p ≤ 0.05 Wilcoxon signed ranks test. cLymphocytes and alveolar macrophages were not detectable in the BALF of three animals out of the infection group
  3. ND = not detectable because below detection limit
  4. Significant values are marked in bold
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