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Table 1 Categories of clinical signs shown by Francisella tularensis ssp. holarctica infected Fischer 344 rats

From: Comparison of virulence of Francisella tularensis ssp. holarctica genotypes B.12 and B.FTNF002-00

Severity of disease Clinical signs
Mild weight loss, accumulation of porphyrin around the eyes (one or both sides), nasal discharge
Moderate weight loss, marked porphyrin secretion around the eyes (one or both sides), nasal discharge, ruffled fur, decreased activity, diarrhoea
Severe weight loss, marked porphyrin secretion around the eyes (both sides), nasal discharge, ruffled fur, inactivity, diarrhoea, laboured breathing, weakness