Skip to main content

Table 5 Parameters of PK/PD modeling based on ex vivo serum data after p.o. administration of sarafloxacin in muscovy ducks (n = 12)

From: Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks

Parameter Unit E. coli O78
Log E 0 CFU/mL 3.58 ± 0.27
Log E 0 − Log E max CFU/mL 8.31 ± 0.28
Slope(N) 3.42 ± 0.15
AUC0-24 h/MIC for bacteriostatic action h 25.4 ± 1.68
AUC0-24 h/MIC EC50 h 27.5 ± 1.86
AUC0-24 h/MIC for bactericidal action h 40.6 ± 2.46
AUC0-24 h/MIC for bacterial eradication h 94.5 ± 7.70
  1. E 0: difference in bacterial count in control sample between time 0 and 24 h; E max: difference in bacterial count in sample containing sarafloxacin between time 0 and 24 h, when limit of detection is reached; N: the Hill coefficient; AUC0-24 h/MIC EC50: AUC0-24 h/MIC of drug producing 50% of the maximum antibacterial effect