TY - JOUR AU - Yu, Yang AU - Zhou, Yu Feng AU - Sun, Jian AU - Shi, Wei AU - Liao, Xiao Ping AU - Liu, Ya Hong PY - 2017 DA - 2017/02/10 TI - Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks JO - BMC Veterinary Research SP - 47 VL - 13 IS - 1 AB - This study focused on utilizing pharmacokinetics/pharmacodynamics (PK/PD) modeling to optimize therapeutic dosage regimens of sarafloxacin against avian pathogenic Escherichia. coli O78 strain in Muscovy ducks. The ex vivo PK/PD study of sarafloxacin was conducted in Muscovy ducks after intravenous (i.v.) and oral (p.o.) administrations at a single dose of 10 mg/kg bodyweight (BW). The serum samples were analyzed by reverse phase high-performance liquid chromatography (RP-HPLC) using a fluorescence detection method. Sarafloxacin PK data were analyzed by a non-compartmental method using Winnonlin software. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-017-0964-0 DO - 10.1186/s12917-017-0964-0 ID - Yu2017 ER -