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Table 4 Decrease in monthly seizure frequency, completer population

From: Clinical evaluation of a combination therapy of imepitoin with phenobarbital in dogs with refractory idiopathic epilepsy

     95% Confidence Interval   % of animals with
Variable Cohort N %Decrease LCL UCL p-value any reduction >50% reduction
MSF A 5 73.42 −20.92 94.16 0.072 80.0 80.0
B 9 37.12 −2.43 61.36 0.059 88.9 33.3
C 5 43.56 −14.11 72.06 0.087 80.0 40.0
A + B 14 53.74 20.31 73.15 0.009 85.7 50.0
A + B + C 19 51.28 26.58 67.63 0.002 84.2 47.4
MCD A 5 59.75 −78.25 90.92 0.165   
B 9 25.55 −27.00 56.35 0.239   
C 5 −20.92 −262.19 59.67 0.656   
A + B 14 40.25 −1.21 64.73 0.055   
A + B + C 19 28.04 −12.98 54.21 0.143   
  1. MSF = (Number of Seizures/Number of days) x 28 days. MCD = (Number of Cluster days/Number of days) x 28 days. Significant %Decrease (p < 0.05) is bolded. In addition, the paired t-test was applied to the corresponding log-transformed data values separately for each cohort and the two combinations of cohorts (i.e., cohort A + B and all 3 cohorts combined). The displayed p-value is derived from this paired t-test. The fraction of animals showing any reduction and >50% reduction of MSF (“Responder rate”) is given.