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Table 3 Median, (25th and 75th percentiles) and percentage of median deviation between initial and follow-up samples of biomarkers of tubular damage. In Group 1: dogs that showed proteinuria (UPC > 0.5) before treatment which did not decrease or even increased after treatment; Group 2: dogs that showed proteinuria (UPC > 0.5) before treatment which decreased after treatment

From: Evaluation of various biomarkers for kidney monitoring during canine leishmaniosis treatment

Parameter Group 1 (n = 6) Group 2 (n = 12) Control dogs (n = 10)
Inital Follow up % median deviation Inital Follow up % median deviation
uRBP/Cr (mg/g) 0.880 (0.049–7.453) 0.506 (0.173–8.608) −42.5 0.484 (0.227–2.650) 0.169 (0.037–0.502)* −65.08 0.21 (0–0.99)
uNAG/Cr (UI/g) 18.49 (4.35–98.82) 18.30 (5.64–28.57) −1.03 14.77 (5.31–28.32) 6.20 (3.84–14.56)* −58.02 7.97 (5.27–11.19)
uGGT/Cr (UI/g) 31.3 (20.0–101.8) 28.4 (9.9–95.2) −9.26 15.38 (11.05–90.36) 10.78 (7.44–19.63) −29.91 10.99 (8.37–18.87)
  1. *P<0.05 compared to baseline