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Table 3 Inhibition of COX-1 and COX-2 activity (%) by ASA and SA; calculated based on in vitro assays (mean ± S.D. of experiments with equine blood samples of 6 horses)

From: Pharmacokinetics and in vitro efficacy of salicylic acid after oral administration of acetylsalicylic acid in horses

Concentration (μmol/l) ASA SA
COX I COX II COX I COX II
0.1 9.1 ± 3.6 9.8 ± 4.6 19.6 ± 9.5 4.7 ± 2.3
1.0 30.8 ± 16.0 12.6 ± 8.3 13.0 ± 5.7 15.3 ± 9.3
10.0 87.0 ± 11.5 37.9 ± 29.3 22.8 ± 10.0 10.3 ± 3.4
100.0 93.6 ± 10.3 60.9 ± 23.4 32.2 ± 21.1 –4.7 ± 3.2
1000.0 92.7 ± 12.9 75.7 ± 32.7 65.8 ± 28.4 26.8 ± 11.3