Table 3 Inhibition of COX-1 and COX-2 activity (%) by ASA and SA; calculated based on in vitro assays (mean ± S.D. of experiments with equine blood samples of 6 horses)
Concentration (μmol/l) | ASA | SA | ||
|---|---|---|---|---|
COX I | COX II | COX I | COX II | |
0.1 | 9.1 ± 3.6 | 9.8 ± 4.6 | 19.6 ± 9.5 | 4.7 ± 2.3 |
1.0 | 30.8 ± 16.0 | 12.6 ± 8.3 | 13.0 ± 5.7 | 15.3 ± 9.3 |
10.0 | 87.0 ± 11.5 | 37.9 ± 29.3 | 22.8 ± 10.0 | 10.3 ± 3.4 |
100.0 | 93.6 ± 10.3 | 60.9 ± 23.4 | 32.2 ± 21.1 | –4.7 ± 3.2 |
1000.0 | 92.7 ± 12.9 | 75.7 ± 32.7 | 65.8 ± 28.4 | 26.8 ± 11.3 |