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Table 2 Plasma SA pharmacokinetics data after oral administration of ASA (12.5, 25.0, 50.0 mg/kg) to horses, mean ± S.D. of eight horses per treatment

From: Pharmacokinetics and in vitro efficacy of salicylic acid after oral administration of acetylsalicylic acid in horses

Parameter Units 12.5 mg/kg 25.0 mg/kg 50.0 mg/kg
Cmax μg/ml 19.75 ± 5.22 30.06 ± 7.44 51.66 ± 11.27
Tmax h 2.0 ± 2.5 2.5 ± 2.3 2.2 ± 1.7
CI/F ml/h/kg 82.2 ± 18.4 97.1 ± 19.9 114.0 ± 31.9
AUClast h x μg/ml 154.9 ± 31.8 264.9 ± 63.2 457.1 ± 114.8
λZ 1/h 0.145 ± 0.040 0.148 ± 0.041 0.145 ± 0.061
λZ T½ h 5.1 ± 1.4 5.0 ± 1.3 5.7 ± 2.8
MRT h 7.26 ± 2.13 7.81 ± 1.70 8.39 ± 3.67