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Table 2 Plasma SA pharmacokinetics data after oral administration of ASA (12.5, 25.0, 50.0 mg/kg) to horses, mean ± S.D. of eight horses per treatment

From: Pharmacokinetics and in vitro efficacy of salicylic acid after oral administration of acetylsalicylic acid in horses

Parameter

Units

12.5 mg/kg

25.0 mg/kg

50.0 mg/kg

Cmax

μg/ml

19.75 ± 5.22

30.06 ± 7.44

51.66 ± 11.27

Tmax

h

2.0 ± 2.5

2.5 ± 2.3

2.2 ± 1.7

CI/F

ml/h/kg

82.2 ± 18.4

97.1 ± 19.9

114.0 ± 31.9

AUClast

h x μg/ml

154.9 ± 31.8

264.9 ± 63.2

457.1 ± 114.8

λZ

1/h

0.145 ± 0.040

0.148 ± 0.041

0.145 ± 0.061

λZ T½

h

5.1 ± 1.4

5.0 ± 1.3

5.7 ± 2.8

MRT

h

7.26 ± 2.13

7.81 ± 1.70

8.39 ± 3.67

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BMC Veterinary Research

ISSN: 1746-6148

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