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Table 6 Landing data (summary variables for postoperative time points compared to baseline) for each treatment group and tabluation of treatment effects

From: Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product

  

Treatment groups

Treatment effect

 

Variable

Control

ER-Bup

P-values

Group differences at individual time points

PVF

OP

(−63.97 ± 45.59)

(−50.50 ± 37.44)

0.0026*

ER-Bup > control at 6, 54 h

NO

23.69 ± 40.23

11.63 ± 37.58

0.0169*

 

VI

OP

(−3.89 ± 3.50)

(−6.25 ± 3.22)

<0.0001*

ER-Bup < control at 6, 30, 48, 72 h

NO

8.99 ± 7.23

1.87 ± 4.50

<0.0001*

ER-Bup < control at all time points

SI

PVF

(−52.03 ± 26.02)

(−38.72 ± 18.63)

<0.0001*

ER-Bup > control at 6, 24, 54 h

VI

(−72.28 ± 29.47)

(−54.96 ± 27.10)

<0.0001*

ER-Bup > control at 6, 30, 54 h

Tf1f2

0.012 ± 0.021

0.008 ± 0.010

0.076

 

Tf1h1

0.014 ± 0.029

(−0.015 ± 0.023)

<0.0001*

ER-Bup < control at all time points

  1. Mean ± SD, *indicates significant difference between groups (<0.05)
  2. OP Operated limb, NO Non-operated limb, PVF Peak vertical force, VI vertical impulse, SI symmetry indices, Tf1f2 Time between first and second forelimb strike, Tf1h1 Time between first forelimb and first hindlimb strike, ER-Bup extended release formulation of buprenorphine HCL