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Table 5 Kinetic data (mean ± SD) collected from ER-Bup treated cats that had undergone a unilateral onychectomy and following landing from an elevated

From: Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product

Time

OP PVF (%)

NO PVF (%)

OP VI (%BW/sec)

NO VI (%BW/sec)

SI PVF

SI VI

Tf1f2 (sec)

Tf1h1 (sec)

P-value

<0.0001

0.3800

<0.0001

0.0004

<0.0001

<0.0001

0.0002

<0.0001

0

189.57 ± 52.03

173.68 ± 43.23

16.86 ± 5.82

14.75 ± 5.18

7.95 ± 20.60

14.15 ± 31.55

(−0.0005 ± 0.0071)

0.12 ± 0.027

6

156.33 ± 45.68*

180.15 ± 28.05

11.59 ± 3.53*

13.61 ± 2.83

(−17.02 ± 22.82)*

(−17.54 ± 34.80)*

0.0090 ± 0.012*

0.11 ± 0.020

24

132.74 ± 48.23*

177.95 ± 37.77

10.80 ± 3.45*

18.34 ± 6.15*

(−32.71 ± 28.98)*

(−49.02 ± 42.24)*

0.0040 ± 0.0082

0.11 ± 0.017

30

146.57 ± 35.39*

195.21 ± 51.45

11.79 ± 2.45*

17.76 ± 5.46

(−28.07 ± 25.06)*

(−36.69 ± 34.91)*

0.007 ± 0.0098*

0.12 ± 0.025

48

128.38 ± 36.61*

186.89 ± 31.34

9.91 ± 3.01*

15.55 ± 3.61

(−38.66 ± 28.26)*

(−44.44 ± 37.28)*

0.007 ± 0.0098*

0.10 ± 0.026*

54

136.68 ± 46.94*

183.54 ± 52.03

10.45 ± 2.37*

15.95 ± 5.03

(−30.78 ± 29.88)*

(−30.78 ± 29.88)*

0.008 ± 0.010*

0.095 ± 0.017*

72

133.76 ± 47.14*

188.15 ± 28.06

9.12 ± 1.99*

18.49 ± 7.84*

(−37.39 ± 32.35)*

(−59.57 ± 47.28)*

0.011 ± 0.010*

0.097 ± 0.028*

  1. Mean ± SD, *indicates significant difference from baseline (<0.05)
  2. OP Operated limb, NO Non-operated limb, PVF Peak vertical force, VI vertical impulse, SI symmetry indices, Tf1f2 Time between first and second forelimb strike, Tf1h1 Time between first forelimb and first hindlimb strike