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Table 5 Kinetic data (mean ± SD) collected from ER-Bup treated cats that had undergone a unilateral onychectomy and following landing from an elevated

From: Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product

Time OP PVF (%) NO PVF (%) OP VI (%BW/sec) NO VI (%BW/sec) SI PVF SI VI Tf1f2 (sec) Tf1h1 (sec)
P-value <0.0001 0.3800 <0.0001 0.0004 <0.0001 <0.0001 0.0002 <0.0001
0 189.57 ± 52.03 173.68 ± 43.23 16.86 ± 5.82 14.75 ± 5.18 7.95 ± 20.60 14.15 ± 31.55 (−0.0005 ± 0.0071) 0.12 ± 0.027
6 156.33 ± 45.68* 180.15 ± 28.05 11.59 ± 3.53* 13.61 ± 2.83 (−17.02 ± 22.82)* (−17.54 ± 34.80)* 0.0090 ± 0.012* 0.11 ± 0.020
24 132.74 ± 48.23* 177.95 ± 37.77 10.80 ± 3.45* 18.34 ± 6.15* (−32.71 ± 28.98)* (−49.02 ± 42.24)* 0.0040 ± 0.0082 0.11 ± 0.017
30 146.57 ± 35.39* 195.21 ± 51.45 11.79 ± 2.45* 17.76 ± 5.46 (−28.07 ± 25.06)* (−36.69 ± 34.91)* 0.007 ± 0.0098* 0.12 ± 0.025
48 128.38 ± 36.61* 186.89 ± 31.34 9.91 ± 3.01* 15.55 ± 3.61 (−38.66 ± 28.26)* (−44.44 ± 37.28)* 0.007 ± 0.0098* 0.10 ± 0.026*
54 136.68 ± 46.94* 183.54 ± 52.03 10.45 ± 2.37* 15.95 ± 5.03 (−30.78 ± 29.88)* (−30.78 ± 29.88)* 0.008 ± 0.010* 0.095 ± 0.017*
72 133.76 ± 47.14* 188.15 ± 28.06 9.12 ± 1.99* 18.49 ± 7.84* (−37.39 ± 32.35)* (−59.57 ± 47.28)* 0.011 ± 0.010* 0.097 ± 0.028*
  1. Mean ± SD, *indicates significant difference from baseline (<0.05)
  2. OP Operated limb, NO Non-operated limb, PVF Peak vertical force, VI vertical impulse, SI symmetry indices, Tf1f2 Time between first and second forelimb strike, Tf1h1 Time between first forelimb and first hindlimb strike