Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs

BMC Veterinary Research

Table 3 Values of the inflammatory, hemostatic and endothelial biomarkers measured in this study in normal weight and overweight/obese dogs

Parameter/unit	Normal weight	Dogs	Overweight	And obese dogs	R and P -value
Parameter/unit	Mean ± SEM	Median; CI (P 25–P 75)	Mean ± SEM	Median; CI (P 25–P 75)
sICAM-1 μg/ml	320 ±13	321; 275–356	329 ± 8.2	326; 288–361	9.021; pd 0.536
IL–6 pg/ml	227 ± 8.9	220; 197–256	261 ± 4.9	259; 235–287	34.829; pd 0.001 **
HMGB-1 ng/ml	85 ± 4.5	83; 70–93	89 ± 2.6	89; 76–98	4.343; pd 0.384
hsCRP μg/ml	3.7 ± 0.17	3.7; 3.2–4.3	4.2 ± 0.14	3.9; 3.6–4.7	0.502; pd 0.027 *
suPAR pg/ml	2598 ± 136	2559; 2195–2923	1990 ± 126	1869; 1542–2486	−608.314; pd 0.002 *
PAI-1 ng/ml	70 ± 5.9	61; 44–94	75 ± 6.9	70; 43–86	1.145; np 0.611
FIB g/L	2.6 ± 0.16	2.6; 2.0–3.0	3.0 ± 0.20	2.6; 2.2–3.5	1.312; np 0.185
FIX %	96 ± 5.6	93; 77–106	112 ± 6.8	100; 84–140	1.385; np 0.081
FVII %	109 ± 6.2	110; 82–136	131 ± 8.7	125; 100–147	1.492; pd 0.054 *
FX %	104 ± 2.2	106; 94–112	115 ± 2.9	110; 102–128	11.557; pd 0.007 **
PT sec	6.1 ± 0.04	6.1; 6.0–6.2	6.1 ± 0.04	6.1 6.0–6.2	0.989; np 0.580
aPTT sec	11 ± 0.23	11; 10–12	10 ± 0.20	10; 9.3–11	−0.749; pd 0.022 *
MPV fl	8.3 ± 0.14	8; 8–9	8.6 ± 0.17	8; 8–9	0.318; pd 0.169
PLT x10⁹/L	234 ± 13	228; 201–265	315 ± 18	298; 253–401	80.916; pd 0.001 **

HMGB-1 high mobility group box – 1 protein, sICAM-1 soluble intercellular adhesive molecule -1, IL-6 interleukin – 6, hsCRP high sensitivity C reactive protein, PAI-1 plasminogen activator inhibitor type 1, suPAR soluble plasminogen activator receptor, FIB fibrinogen, FX, FIX, FVII clotting factors X, IX and VII, PT prothrombine time, aPTT activated partial thromboplastine time, MPV mean platelet volume, PLT number of platelets, np nonparametric distribution, pd parametric distribution
*p ≤ 0.05, **p < 0.01,

ISSN: 1746-6148