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Table 3 Values of the inflammatory, hemostatic and endothelial biomarkers measured in this study in normal weight and overweight/obese dogs

From: Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs

Parameter/unit Normal weight Dogs Overweight And obese dogs R and P -value
Mean ± SEM Median; CI (P 25–P 75) Mean ± SEM Median; CI (P 25–P 75)  
sICAM-1 μg/ml 320 ±13 321; 275–356 329 ± 8.2 326; 288–361 9.021; pd 0.536
IL–6 pg/ml 227 ± 8.9 220; 197–256 261 ± 4.9 259; 235–287 34.829; pd 0.001 **
HMGB-1 ng/ml 85 ± 4.5 83; 70–93 89 ± 2.6 89; 76–98 4.343; pd 0.384
hsCRP μg/ml 3.7 ± 0.17 3.7; 3.2–4.3 4.2 ± 0.14 3.9; 3.6–4.7 0.502; pd 0.027 *
suPAR pg/ml 2598 ± 136 2559; 2195–2923 1990 ± 126 1869; 1542–2486 −608.314; pd 0.002 *
PAI-1 ng/ml 70 ± 5.9 61; 44–94 75 ± 6.9 70; 43–86 1.145; np 0.611
FIB g/L 2.6 ± 0.16 2.6; 2.0–3.0 3.0 ± 0.20 2.6; 2.2–3.5 1.312; np 0.185
FIX % 96 ± 5.6 93; 77–106 112 ± 6.8 100; 84–140 1.385; np 0.081
FVII % 109 ± 6.2 110; 82–136 131 ± 8.7 125; 100–147 1.492; pd 0.054 *
FX % 104 ± 2.2 106; 94–112 115 ± 2.9 110; 102–128 11.557; pd 0.007 **
PT sec 6.1 ± 0.04 6.1; 6.0–6.2 6.1 ± 0.04 6.1 6.0–6.2 0.989; np 0.580
aPTT sec 11 ± 0.23 11; 10–12 10 ± 0.20 10; 9.3–11 −0.749; pd 0.022 *
MPV fl 8.3 ± 0.14 8; 8–9 8.6 ± 0.17 8; 8–9 0.318; pd 0.169
PLT x109/L 234 ± 13 228; 201–265 315 ± 18 298; 253–401 80.916; pd 0.001 **
  1. HMGB-1 high mobility group box – 1 protein, sICAM-1 soluble intercellular adhesive molecule -1, IL-6 interleukin – 6, hsCRP high sensitivity C reactive protein, PAI-1 plasminogen activator inhibitor type 1, suPAR soluble plasminogen activator receptor, FIB fibrinogen, FX, FIX, FVII clotting factors X, IX and VII, PT prothrombine time, aPTT activated partial thromboplastine time, MPV mean platelet volume, PLT number of platelets, np nonparametric distribution, pd parametric distribution
  2. *p ≤ 0.05, **p < 0.01,