TY - JOUR AU - Grimes, Janet A. AU - Prasad, Nripesh AU - Levy, Shawn AU - Cattley, Russell AU - Lindley, Stephanie AU - Boothe, Harry W. AU - Henderson, Ralph A. AU - Smith, Bruce F. PY - 2016 DA - 2016/12/03 TI - A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs JO - BMC Veterinary Research SP - 272 VL - 12 IS - 1 AB - Splenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulation, and differential expression of miRNAs between normal and tumor tissue has been used to diagnose neoplastic diseases. The objective of this study was to determine differential expression of miRNAs by use of RNA-sequencing in canine spleens that were histologically confirmed as hemangiosarcoma, nodular hyperplasia, or normal. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-016-0903-5 DO - 10.1186/s12917-016-0903-5 ID - Grimes2016 ER -