The using of a piglets as a model for evaluating the dipyrone hematological effects

BMC Veterinary Research

Table 1 Dynamics of changes in blood parameters expressed as minimum, maximum, and area under the curve effect (AUEC) in piglets, after a single I.M. administration of dipyrone at a dose of 100 mg/kg

Blood analysis	Dynamic range of effect minimal to maximal (M; SD)		AUEC (M; SD)		A/B ratio	A/B p-value
Blood analysis	Dynamic range of effect minimal to maximal (M; SD)		A	B	A/B ratio	A/B p-value
APTT	113.59; 25.95	45.14; 11.04	4766.87; 542.43	2968.43; 588.85	0.197	0.0207
APTT_ratio	3.36; 0.77	1.33; 0.33	140.69; 16.01	86.38; 17.14	0.186	0.0259
Hb	12.35; 0.58	9.14; 0.49	628.56; 74.74	450.96; 20.44	0.303	0.0001
Hct	36.32; 1.63	26.64; 1.70	1808.43; 213.89	2586.93; 58.18	0.650	0.0001
MCH	19.65; 0.88	17.58; 0.91	1198.07; 139.58	707.33; 33.62	0.153	0.0046
MCV	58.00; 2.60	51.25; 3.53	3440.34; 406.96	2019.75; 113.64	0.148	0.0052
RBC	6.56; 0.33	5.22; 0.37	362.90; 42.88	229.96; 10.74	0.211	0.0001
WBC	24.67; 2.14	14.71; 1.76	1267.83; 179.64	476.63; 41.72	−0.330	0.0006
PT	95.00; 6.08	77.25; 3.67	5164.33; 699.57	3207.75; 406.96	0.195	0.0076

M arithmetic mean, SD standard deviation, A area under effect curve at time 0 to 72 h (after treatment), B area under effect curve at baseline (time between 36 h before treatment and time zero), A/B ratio calculated from A and B value, APTT activated partial thromboplastin time, APTT _ratio ratio of activated partial thromboplastin time, Hb hemoglobin (g/dL), Hct hematocrit (%), MCH mean corpuscular hemoglobin (pg), MCV mean corpuscular volume (fL), RBC red blood cells volume (×10¹² L), WBC white blood cells volume (×10⁹ L), PT prothrombin time index (%); p-value – calculated between A/72 and B/36

ISSN: 1746-6148