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Table 2 Distribution of avian influenza virus antigen visualized by immunohistochemical staining in tissues by isolate

From: H5N2 Highly Pathogenic Avian Influenza Viruses from the US 2014-2015 outbreak have an unusually long pre-clinical period in turkeys

Bird ID

Detection of avian influenza virus antigen in tissues

Nasal epithelium

Nasal glands

Trachea

Lung

Heart

Brain

Liver

Kidney

Adrenal gland

Spleen

Intestine

Pancreas

Harderian gland

Thymus

Bursa

Proventric

A/Northern Pintail/WA/40964/2014

1043

+

+

+

++

+++

+

+

+++

+

+

+++

+

1045

+

++

+

+

+++

+++

+

+++

++

++

+

1047

+

+

+

+

+++

+

+

+++

+

+

+++

+

+

++

+

1052

+

++

+

+++

+

++

++

+

 

+

+

1053

+

++

++

+++

+

+

++

++

+++

+

+

++

1056

++

++

+

++

++

+++

+

++

+++

+++

++

+

++

++

+

A/turkey/MN/12528/2015

1093

++

+++

+

++

+++

+

++

+

+

+

1097

+

++

+

+

+++

+++

++

+

++

+

++

+++

+

+

+++

A/chicken/IA/13388/2015

1040

+

+

+

+++

+++

+

+

+++

+

+++

+

+

1050

+

++

+

++

+++

+

++

+++

+

++

  1. Turkeys were selected for examination because they were presenting with clinical illness at 4 days post challenge (DPC) (A/Northern Pintail/WA/40964/2014) or 3DPC (A/turkey/MN/12528/2015 and A/chicken/IA/13388/2015)
  2. − = no positive cells; + = single positive cells; ++ = scattered groups of positive cells; +++ = widespread staining
  3. Proventric. = proventriculus