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Table 2 Distribution of avian influenza virus antigen visualized by immunohistochemical staining in tissues by isolate

From: H5N2 Highly Pathogenic Avian Influenza Viruses from the US 2014-2015 outbreak have an unusually long pre-clinical period in turkeys

Bird ID Detection of avian influenza virus antigen in tissues
Nasal epithelium Nasal glands Trachea Lung Heart Brain Liver Kidney Adrenal gland Spleen Intestine Pancreas Harderian gland Thymus Bursa Proventric
A/Northern Pintail/WA/40964/2014
1043 + + + ++ +++ + + +++ + + +++ +
1045 + ++ + + +++ +++ + +++ ++ ++ +
1047 + + + + +++ + + +++ + + +++ + + ++ +
1052 + ++ + +++ + ++ ++ +   + +
1053 + ++ ++ +++ + + ++ ++ +++ + + ++
1056 ++ ++ + ++ ++ +++ + ++ +++ +++ ++ + ++ ++ +
A/turkey/MN/12528/2015
1093 ++ +++ + ++ +++ + ++ + + +
1097 + ++ + + +++ +++ ++ + ++ + ++ +++ + + +++
A/chicken/IA/13388/2015
1040 + + + +++ +++ + + +++ + +++ + +
1050 + ++ + ++ +++ + ++ +++ + ++
  1. Turkeys were selected for examination because they were presenting with clinical illness at 4 days post challenge (DPC) (A/Northern Pintail/WA/40964/2014) or 3DPC (A/turkey/MN/12528/2015 and A/chicken/IA/13388/2015)
  2. − = no positive cells; + = single positive cells; ++ = scattered groups of positive cells; +++ = widespread staining
  3. Proventric. = proventriculus