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Table 1 Mortality, mean death time, 50% infectious dose, 50% lethal dose and number of birds shedding for three H5N2 highly pathogenic avian influenza viruses in 4-week old directly inoculated and contact exposed broad-breasted white turkeys

From: H5N2 Highly Pathogenic Avian Influenza Viruses from the US 2014-2015 outbreak have an unusually long pre-clinical period in turkeys

Isolate Dose (EID50/bird) Mortality Mean death time (days) Number of turkeys shedding Seroconversion 50% Turkey infectious dosee
Inoculated Contact exposed Inoculated Contact exposed Inoculated Contact exposed Inoculated Contact exposed
A/northern pintail/WA/40964/2014 102 0/5a 0/3a NAb NA 0/5d 0/3d 0/5i 0/3i 105 EID50 f
104 0/5 0/3 NA NA 0/5 0/3 0/5 0/3
106 5/5 3/3 5.3 (4–7)gh 7.6 (7–8)cg 5/5 3/3 NA NA
106 16/16 NA NA 16/16 NA NA NA
A/turkey/MN/12582/2015 102 0/5 0/3 NA NA 0/5 0/3 0/5 0/3 105 EID50
104 0/5 0/3 NA NA 0/5 0/3 0/5 0/3
106 5/5 3/3 5.9 (3–10) 8.0 (6–10) 5/5 3/3 NA NA
106 16/16 NA NA 16/16 NA NA NA
A/chicken/IA/13388/2015 102 0/5 0/3 NA NA 0/5 0/3 0/5 0/3 103 EID50
104 5/5 3/3 5.4 (1–7) 9.0 (6–10) 3/5 3/3 NA NA
106 5/5 3/3 5.6 (3–13) 7.6 (2–13) 5/5 3/3 NA NA
106 16/16 NA NA 16/16 NA NA NA
  1. aNumber dead/total
  2. b NA not applicable. Either no mortality or no birds survived for antibody testing
  3. cCalculated from the day of placement with the inoculated turkeys
  4. dNumber shedding/total
  5. e50% infectious dose was equal to the 50% lethal dose for all isolates
  6. fEID50 = 50% egg infectious dose
  7. gMean death time days (range of mortality in days). For inoculated birds includes data from all 21 turkeys exposed to 106 EID50/bird
  8. hMean death times are combined for directly exposed turkeys in the same dose group for each isolate
  9. iNumber seroconverted/total