Skip to main content
Fig. 1 | BMC Veterinary Research

Fig. 1

From: Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach

Fig. 1

Schematic representation of the final pharmacokinetic model for plasma tulathromycin concentrations and milk cumulative excreted amounts of tulathromycin marker residue CP-60,300 in lactating goats. A 1 is the total amount in the central compartment (ng); A a is the amount in the absorption compartment via SC injection (ng); A 2 is the total amount in peripheral compartment (ng); A milk is the cumulative excreted amount in the milk (ng); Cl is central clearance (mL/h); Cl 2 is clearance between the central and the peripheral compartment (mL/h); Cl milk is clearance from the central compartment to the milk (mL/h); K a is absorption rate constant after SC injection (1/h); V is volume of distribution for the central compartment (mL); V 2 is volume of distribution for the peripheral compartment (mL)

Back to article page