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Table 2 Surrogate markers of efficacy from pharmacokinetics parameters after IV, SC and SC-LA administraton of ceftiofur, calculated for a mean MIC, MBC and MPC of ceftiofur on M. haemolytica strains isolated from goats (n = 5)

From: Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats

Parameter

IV

SC

SC-LA

Mean MIC (M. haemolytica) = 0.0436 μg/mL

 Cmax/MIC

--

130.53 ± 28.65

145.47 ± 22.55

 AUC0-∞/MIC (h)

1079.16 ± 157

914.77 ± 143

2686.34 ± 264

 AUC24/MIC (h)

1043.80 ± 155

875.38 ± 160

1952.44 ± 173

 T > MIC (h)

24 h

24 h

72 h

Mean MBC (M. haemolytica) = 0.10 μg/mL

 Cmax/MBC

--

56.91 ± 12.49

63.42 ± 9.83

 AUC0-∞/MBC (h)

470.51 ± 68.46

398.84 ± 62.60

1171.24 ± 115.4

 AUC24/MBC (h)

455.1 ± 67.98

381.66 ± 69.78

851.27 ± 75.36

 T > MBC (h)

24 h

24 h

72 h

Mean MPC (M. haemolytica) = 0.55 μg/mL

 Cmax/MPC

--

10.34 ± 2.27

11.53 ± 1.79

 AUC0-∞/MPC (h)

85.54 ± 12.36

72.51 ± 11.38

212.95 ± 20.98

 AUC24/MPC (h)

82.74 ± 12.36

69.39 ± 12.69

154.77 ± 13.70

 T > MPC (h)

12 h

12 h

32 h