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Table 2 Surrogate markers of efficacy from pharmacokinetics parameters after IV, SC and SC-LA administraton of ceftiofur, calculated for a mean MIC, MBC and MPC of ceftiofur on M. haemolytica strains isolated from goats (n = 5)

From: Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of ceftiofur after a single intravenous, subcutaneous and subcutaneous-LA administration in lactating goats

Parameter IV SC SC-LA
Mean MIC (M. haemolytica) = 0.0436 μg/mL
 Cmax/MIC -- 130.53 ± 28.65 145.47 ± 22.55
 AUC0-∞/MIC (h) 1079.16 ± 157 914.77 ± 143 2686.34 ± 264
 AUC24/MIC (h) 1043.80 ± 155 875.38 ± 160 1952.44 ± 173
 T > MIC (h) 24 h 24 h 72 h
Mean MBC (M. haemolytica) = 0.10 μg/mL
 Cmax/MBC -- 56.91 ± 12.49 63.42 ± 9.83
 AUC0-∞/MBC (h) 470.51 ± 68.46 398.84 ± 62.60 1171.24 ± 115.4
 AUC24/MBC (h) 455.1 ± 67.98 381.66 ± 69.78 851.27 ± 75.36
 T > MBC (h) 24 h 24 h 72 h
Mean MPC (M. haemolytica) = 0.55 μg/mL
 Cmax/MPC -- 10.34 ± 2.27 11.53 ± 1.79
 AUC0-∞/MPC (h) 85.54 ± 12.36 72.51 ± 11.38 212.95 ± 20.98
 AUC24/MPC (h) 82.74 ± 12.36 69.39 ± 12.69 154.77 ± 13.70
 T > MPC (h) 12 h 12 h 32 h