Fig. 10

Changes in FcRn expression in mucosal epithelium of abomasum ALNA with age. Diagram a to d represent the changes in FcRn expression with age in FAE of RMFR, non-FAE of RMFR, FAE of LMFR, non-FAE of LMFR, respectively. Red lines represent increase with age, and black lines represent decrease with age. The results showed that in the FAE and non-FAE of RMFR, the FcRn expression level peaked at the pubertal period, and then significant decreased with age. The case was similar in the FAE of LMFR, however, the FcRn expression level in non-FAE of LMFR peaked at Middle-aged period, and then significant decreased with age. It probably related to the upregulation of compensatory reflection because of the FcRn expression level was decreased in other site in this period. In Old group, the FcRn expression level was very low, and it probably related to the degradation of the mucosal immune or immunosenescence